Regular ArticlesEpstein-Barr Virus (EBV) Latent Membrane Protein-1 Down-Regulates Tumor Necrosis Factor-α (TNF-α) Receptor-1 and Confers Resistance to TNF-α-Induced Apoptosis in T Cells: Implication for the Progression to T-Cell Lymphoma in EBV-Associated Hemophagocytic Syndrome
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Supported by the National Health Research Institutes and the National Science Council, Taipei, Taiwan (to I.-J.S.).
H.-C.C. and J.-D.L. contributed equally in this study.
H.-C.C., a Ph.D. student, performed the apoptotic studies, TNFR1 regulation by LMP-1, reconstitution studies, and wrote the manuscript; J.-D.L., a post-doctor, performed the TRAFs/TRADD pathway, caspase studies, and promoter assay; S.-E.C. and Y.C. discussed and supervised the studies; W.-C.H. performed the cytokine assay; and I.-J.S. designed and supervised the studies and finished the manuscript.
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