p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology, and human risk assessment

S P Hussain; M H Hollstein; C C Harris

doi:10.1111/j.1749-6632.2000.tb06870.x

p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology, and human risk assessment

Ann N Y Acad Sci. 2000:919:79-85. doi: 10.1111/j.1749-6632.2000.tb06870.x.

Authors

S P Hussain¹, M H Hollstein, C C Harris

Affiliation

¹ Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, USA.

PMID: 11083100
DOI: 10.1111/j.1749-6632.2000.tb06870.x

Abstract

The molecular archaeology of the mutation spectra of tumor suppressor genes generates hypotheses concerning the etiology and molecular pathogenesis of human cancer. The spectrum of somatic mutations in the p53 gene implicates environmental carcinogens and both endogenous agents and processes in the etiology of human cancer.

MeSH terms

Aflatoxin B1 / toxicity
Carcinogens / pharmacology
DNA Mutational Analysis
Genes, p53 / genetics*
Genes, p53 / physiology
Genetic Predisposition to Disease
Humans
Liver Neoplasms / chemically induced
Liver Neoplasms / etiology
Liver Neoplasms / genetics
Mutagens / pharmacology
Neoplasms / chemically induced
Neoplasms / epidemiology
Neoplasms / etiology*
Neoplasms / genetics*
Oncogenes / genetics
Risk Assessment
Skin Neoplasms / etiology
Skin Neoplasms / genetics
Sunlight / adverse effects

Substances

Carcinogens
Mutagens
Aflatoxin B1