Abstract
The evolutionarily ancient intracellular stress response protects cells from the effects of external and internal forces which perturb cellular metabolism. Members of the major histocompatibility complex (MHC) class I-like superfamily act as cell surface indicators of the intracellular stress response. Cellular immunity employs these indicators as a cue for elimination of damaged, infected, and malignant cells, promoting the health of the individual and the evolutionary success of the species.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Biomarkers
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Chaperonin 60 / metabolism
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Evolution, Molecular
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Histocompatibility Antigens Class I / genetics
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Histocompatibility Antigens Class I / physiology*
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Humans
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Mice
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Multigene Family
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Receptors, Immunologic / metabolism
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Receptors, Natural Killer Cell
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T-Lymphocytes / immunology
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T-Lymphocytes / metabolism
Substances
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Biomarkers
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Chaperonin 60
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Histocompatibility Antigens Class I
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Receptors, Immunologic
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Receptors, Natural Killer Cell