The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

Arlene H Sharpe; E John Wherry; Rafi Ahmed; Gordon J Freeman

doi:10.1038/ni1443

The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

Nat Immunol. 2007 Mar;8(3):239-45. doi: 10.1038/ni1443.

Authors

Arlene H Sharpe¹, E John Wherry, Rafi Ahmed, Gordon J Freeman

Affiliation

¹ Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. arlene_sharpe@hms.harvard.edu

PMID: 17304234
DOI: 10.1038/ni1443

Abstract

The programmed cell death 1 (PD-1) surface receptor binds to two ligands, PD-L1 and PD-L2. Studies have shown that PD-1-PD-L interactions control the induction and maintenance of peripheral T cell tolerance and indicate a previously unknown function for PD-L1 on nonhematopoietic cells in protecting tissues from autoimmune attack. PD-1 and its ligands have also been exploited by a variety of microorganisms to attenuate antimicrobial immunity and facilitate chronic infection. Here we examine the functions of PD-1 and its ligands in regulating antimicrobial and self-reactive T cell responses and discuss the therapeutic potential of manipulating this pathway.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antigens, CD / genetics
Antigens, CD / immunology*
Antigens, CD / metabolism
Autoimmunity*
B7-H1 Antigen
Communicable Diseases / immunology*
Humans
Immune Tolerance
Intercellular Signaling Peptides and Proteins / immunology*
Intercellular Signaling Peptides and Proteins / metabolism
Lymphocyte Activation / immunology
Models, Immunological*
Programmed Cell Death 1 Ligand 2 Protein

Substances

Antigens, CD
B7-H1 Antigen
CD274 protein, human
Intercellular Signaling Peptides and Proteins
PDCD1LG2 protein, human
Programmed Cell Death 1 Ligand 2 Protein