Abstract
The ISCOMATRIX adjuvant has antigen-delivery and -presentation properties, as well as immunomodulatory capabilities that combine to provide enhanced and accelerated immune responses. The responses are broad, including a range of subclasses of antibodies as well as both CD4+ and CD8+ T cells. A range of ISCOMATRIX vaccines (ISCOMATRIX adjuvant combined with antigen) have been evaluated in clinical trials. The results of these completed and ongoing studies indicate that the ISCOMATRIX adjuvant is safe and generally well tolerated and increases the vaccine immune responses.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adjuvants, Immunologic / administration & dosage*
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Adjuvants, Pharmaceutic / administration & dosage
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Animals
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Cholesterol / administration & dosage*
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Cholesterol / immunology
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Clinical Trials as Topic / methods
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Drug Combinations
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Humans
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Phospholipids / administration & dosage*
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Phospholipids / immunology
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Saponins / administration & dosage*
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Saponins / immunology
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Vaccines / administration & dosage*
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Vaccines / immunology
Substances
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Adjuvants, Immunologic
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Adjuvants, Pharmaceutic
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Drug Combinations
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ISCOMATRIX
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Phospholipids
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Saponins
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Vaccines
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Cholesterol