Abstract
Regulatory T cells control immune responses to self- and foreign-antigens and play a major role in maintaining the balance between immunity and tolerance. This article reviews recent key developments in the field of CD4+CD25+Foxp3+ regulatory T (TREG) cells. It presents their characteristics and describes their range of activity and mechanisms of action. Some models of diseases triggered by the imbalance between TREG cells and effector pathogenic T cells are described and their potential therapeutic applications in humans are outlined.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigens, CD / immunology
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Antigens, Differentiation / immunology
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CTLA-4 Antigen
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Forkhead Transcription Factors / immunology
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Forkhead Transcription Factors / physiology*
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Forkhead Transcription Factors / therapeutic use
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Humans
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Immune Tolerance / physiology
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Interleukin-10 / immunology
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Interleukin-10 / physiology
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Interleukin-2 / immunology
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Interleukin-2 / physiology
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Receptors, Interleukin-2 / immunology
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Receptors, Interleukin-2 / physiology
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T-Lymphocytes, Regulatory / immunology
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T-Lymphocytes, Regulatory / physiology*
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Transforming Growth Factor beta / immunology
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Transforming Growth Factor beta / physiology
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Transplantation Immunology
Substances
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Antigens, CD
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Antigens, Differentiation
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CTLA-4 Antigen
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CTLA4 protein, human
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FOXP3 protein, human
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Forkhead Transcription Factors
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Interleukin-2
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Receptors, Interleukin-2
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Transforming Growth Factor beta
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Interleukin-10