Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1

N Engl J Med. 2008 Jun 19;358(25):2698-703. doi: 10.1056/NEJMoa0800251.

Abstract

We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Neoplasm / blood
  • Antigens, Neoplasm / immunology*
  • CD4-Positive T-Lymphocytes / immunology*
  • Humans
  • Immunoglobulin G / blood
  • Immunotherapy*
  • Male
  • Melanoma / immunology
  • Melanoma / secondary
  • Melanoma / therapy*
  • Membrane Proteins / immunology*
  • Middle Aged
  • Remission Induction / methods

Substances

  • Antibodies, Neoplasm
  • Antigens, Neoplasm
  • CTAG1B protein, human
  • Immunoglobulin G
  • Membrane Proteins