Abstract
The present study was performed to determine IL-10 expression in cervical tissues in Mexican women according to the severity of the malignity and its association with HPV infection. IL-10 expression showed a clear tendency to increase during the different cervical cancer stages: 37% in LGSIL; 62% in HGSIL; and 84% in cancer. However, all the patients that expressed IL-10 were HPV positives; we found an association with HPV 16. These results suggest a clear relationship between IL-10, HPV and the stage of cervical cancer disease; this event could contribute to the immunosuppressive micro-environment in the tumor site.
MeSH terms
-
DNA Primers
-
DNA, Neoplasm / genetics
-
DNA, Neoplasm / isolation & purification
-
Female
-
Gene Expression Regulation, Neoplastic*
-
Humans
-
Interleukin-10 / genetics*
-
Mexico
-
Neoplasm Staging
-
Papillomavirus Infections / complications*
-
Papillomavirus Infections / epidemiology
-
Papillomavirus Infections / immunology*
-
Prevalence
-
RNA, Messenger / genetics
-
RNA, Neoplasm / genetics
-
RNA, Neoplasm / isolation & purification
-
Reverse Transcriptase Polymerase Chain Reaction
-
Uterine Cervical Neoplasms / complications
-
Uterine Cervical Neoplasms / genetics*
-
Uterine Cervical Neoplasms / immunology
-
Uterine Cervical Neoplasms / pathology*
Substances
-
DNA Primers
-
DNA, Neoplasm
-
RNA, Messenger
-
RNA, Neoplasm
-
Interleukin-10