Abstract
BCG, a live attenuated tubercle bacillus, is the most widely used vaccine in the world and is also a useful vaccine vehicle for delivering protective antigens of multiple pathogens. Extrachromosomal and integrative expression vectors carrying the regulatory sequences for major BCG heat-shock proteins have been developed to allow expression of foreign antigens in BCG. These recombinant BCG strains can elicit long-lasting humoral and cellular immune responses to foreign antigens in mice.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antigens / genetics*
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Antigens / immunology
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Antigens, Bacterial / genetics
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Antigens, Bacterial / immunology
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Antigens, Viral / genetics
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Antigens, Viral / immunology
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BCG Vaccine / genetics*
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BCG Vaccine / immunology
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Base Sequence
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Cloning, Molecular
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Escherichia coli / genetics
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Gene Expression
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Genes, Bacterial
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Genetic Vectors*
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HIV Antigens / genetics
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HIV-1 / immunology
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Heat-Shock Proteins / genetics
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Mice
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Mice, Inbred BALB C
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Molecular Sequence Data
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Mycobacterium bovis / genetics*
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Regulatory Sequences, Nucleic Acid
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Vaccines, Synthetic / genetics*
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Vaccines, Synthetic / immunology
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beta-Galactosidase / genetics
Substances
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Antigens
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Antigens, Bacterial
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Antigens, Viral
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BCG Vaccine
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HIV Antigens
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Heat-Shock Proteins
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Vaccines, Synthetic
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beta-Galactosidase