Abstract
Human pathologies such as vascular malformations, hemorrhagic stroke, and edema have been associated with defects in the organization of endothelial cell junctions. Understanding the molecular basis of these diseases requires different integrated approaches which include basic cell biology, clinical studies, and studies in animal models such as mice and zebrafish. In this review we discuss recent findings derived from these approaches and their possible integration in a common picture.
Publication types
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigens, CD / metabolism
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Binding Sites
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Cadherins / metabolism
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Capillary Permeability
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Cyclic AMP / metabolism
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Disease Models, Animal
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Endothelium, Vascular / pathology*
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Humans
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Intercellular Junctions / metabolism
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Mice
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Mice, Transgenic
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Models, Biological
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Phenotype
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Signal Transduction
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rap1 GTP-Binding Proteins / metabolism
Substances
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Antigens, CD
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Cadherins
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cadherin 5
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Cyclic AMP
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rap1 GTP-Binding Proteins