Abstract
CD57(+) expression in T lymphocytes has been recognized for decades as a marker of in vitro replicative senescence. In recent years, accumulating evidences have pointed on the utility of this marker to measure functional immune deficiency in patients with autoimmune disease, infectious diseases, and cancers. We review here the relevant literature and implications in clinical settings.
MeSH terms
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Autoimmune Diseases / immunology*
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Autoimmune Diseases / pathology
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Biomarkers
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CD57 Antigens / analysis*
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CD8-Positive T-Lymphocytes / chemistry
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CD8-Positive T-Lymphocytes / immunology*
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CD8-Positive T-Lymphocytes / pathology
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Cellular Senescence / immunology*
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Humans
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Immunity, Cellular
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Immunologic Deficiency Syndromes / immunology*
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Infections / immunology*
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Infections / pathology
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Neoplasms / immunology*
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Neoplasms / pathology
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T-Lymphocyte Subsets / chemistry
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T-Lymphocyte Subsets / immunology*
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T-Lymphocyte Subsets / pathology
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Transplantation Immunology
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Virus Diseases / immunology
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Virus Diseases / pathology