Abstract
This work describes the nature and strength of the immune response induced by various Toll-like receptor ligands and their ability to act as vaccine adjuvants. It reviews the various ligands capable of triggering individual TLRs, and then focuses on the efficacy and safety of those agents for which clinical results are available.
Published by Elsevier Ltd.
MeSH terms
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Adjuvants, Immunologic / administration & dosage
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Adjuvants, Immunologic / adverse effects*
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Adjuvants, Immunologic / pharmacology*
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Humans
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Toll-Like Receptors / drug effects*
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Toll-Like Receptors / immunology*
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Vaccination / adverse effects*
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Vaccination / methods*
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Vaccines / administration & dosage
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Vaccines / immunology*
Substances
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Adjuvants, Immunologic
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Toll-Like Receptors
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Vaccines