Abstract
T-cell receptor alpha- and beta-chain genes were isolated from a class I major histocompatibility complex-restricted cytotoxic T-cell clone and transferred by protoplast fusion into another cytolytic T-cell clone of different specificity. Expression of the transfected alpha and beta genes endowed the recipient cell with the specificity of the donor cell.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alleles
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Animals
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Bacteriophage lambda / genetics
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Base Sequence
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Cell Line
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Clone Cells
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DNA, Recombinant
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Histocompatibility Antigens / immunology
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Hybridomas / immunology
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Mice
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Mice, Inbred C57BL
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Mice, Inbred DBA
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Nucleic Acid Hybridization
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RNA / genetics
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Receptors, Antigen, T-Cell / genetics*
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Receptors, Antigen, T-Cell / immunology
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T-Lymphocytes, Cytotoxic / immunology
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Transcription, Genetic
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Transfection*
Substances
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DNA, Recombinant
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Histocompatibility Antigens
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Receptors, Antigen, T-Cell
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RNA
Associated data
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GENBANK/X03668
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GENBANK/X03669
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GENBANK/X03670
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GENBANK/X03671
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GENBANK/X03760
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GENBANK/X03761
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GENBANK/X03762