IP3 receptors: Take four IP3 to open

Sci Signal. 2016 Apr 5;9(422):pe1. doi: 10.1126/scisignal.aaf6029.

Abstract

Inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors are the channels responsible for Ca(2+)release from the endoplasmic and sarcoplasmic reticulum. Research inScience Signalingby Alzayadyet al show that all four IP3-binding sites within the tetrameric IP3R must bind IP3before the channel can open, which has important consequences for the distribution of both IP3and IP3R activity within cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Calcium / metabolism*
  • Calcium Signaling
  • Humans
  • Inositol 1,4,5-Trisphosphate / chemistry*
  • Inositol 1,4,5-Trisphosphate / metabolism
  • Inositol 1,4,5-Trisphosphate Receptors / chemistry*
  • Inositol 1,4,5-Trisphosphate Receptors / metabolism
  • Ion Channel Gating*
  • Models, Molecular
  • Molecular Structure
  • Protein Binding
  • Protein Domains

Substances

  • Inositol 1,4,5-Trisphosphate Receptors
  • Inositol 1,4,5-Trisphosphate
  • Calcium