Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

Roel Nusse; Hans Clevers

doi:10.1016/j.cell.2017.05.016

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

Cell. 2017 Jun 1;169(6):985-999. doi: 10.1016/j.cell.2017.05.016.

Authors

Roel Nusse¹, Hans Clevers²

Affiliations

¹ Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: rnusse@stanford.edu.
² Hubrecht Institute, University Medical Center Utrecht, Princess Maxima Center for Pediatric Oncology, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.

PMID: 28575679
DOI: 10.1016/j.cell.2017.05.016

Abstract

The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies.

Keywords: Wnt; cancer; development; stem cells; therapy.

Publication types

Review

MeSH terms

Animals
Congenital Abnormalities / metabolism
Humans
Molecular Targeted Therapy
Neoplasms / drug therapy
Neoplasms / metabolism
Organoids / metabolism
Stem Cells / metabolism
Wnt Proteins / chemistry
Wnt Proteins / genetics
Wnt Proteins / metabolism*
Wnt Signaling Pathway* / drug effects

Substances

Wnt Proteins