Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells

Nat Immunol. 2017 Sep;18(9):1004-1015. doi: 10.1038/ni.3800. Epub 2017 Jul 31.

Abstract

Avoiding destruction by immune cells is a hallmark of cancer, yet how tumors ultimately evade control by natural killer (NK) cells remains incompletely defined. Using global transcriptomic and flow-cytometry analyses and genetically engineered mouse models, we identified the cytokine-TGF-β-signaling-dependent conversion of NK cells (CD49a-CD49b+Eomes+) into intermediate type 1 innate lymphoid cell (intILC1) (CD49a+CD49b+Eomes+) populations and ILC1 (CD49a+CD49b-Eomesint) populations in the tumor microenvironment. Strikingly, intILC1s and ILC1s were unable to control local tumor growth and metastasis, whereas NK cells favored tumor immunosurveillance. Experiments with an antibody that neutralizes the cytokine TNF suggested that escape from the innate immune system was partially mediated by TNF-producing ILC1s. Our findings provide new insight into the plasticity of group 1 ILCs in the tumor microenvironment and suggest that the TGF-β-driven conversion of NK cells into ILC1s is a previously unknown mechanism by which tumors escape surveillance by the innate immune system.

MeSH terms

  • Animals
  • Case-Control Studies
  • Cell Line, Tumor
  • Cellular Reprogramming / immunology*
  • Enzyme-Linked Immunosorbent Assay
  • Fibrosarcoma / immunology*
  • Flow Cytometry
  • Gastrointestinal Neoplasms / immunology*
  • Gastrointestinal Stromal Tumors / immunology*
  • Gene Expression Profiling
  • Humans
  • Immunity, Innate / immunology*
  • Killer Cells, Natural / cytology
  • Killer Cells, Natural / immunology*
  • Lymphocytes / cytology
  • Lymphocytes / immunology
  • Mice
  • Neoplasms, Experimental / immunology*
  • Sequence Analysis, RNA
  • Signal Transduction
  • Transforming Growth Factor beta / immunology
  • Tumor Escape / immunology*

Substances

  • Transforming Growth Factor beta