Chemical induction of ovarian epithelial carcinoma in mice

Gynecol Oncol. 1984 Jun;18(2):177-80. doi: 10.1016/0090-8258(84)90025-8.

Abstract

Murine ovaries were treated with silk sutures saturated with a solution of 7,12-dimethylbenz(a)anthracene in beeswax. One of 35 animals developed an epithelial carcinoma. This tumor was not successfully transplanted into young animals.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene*
  • Adenocarcinoma / chemically induced
  • Adenocarcinoma / pathology
  • Adenocarcinoma / ultrastructure
  • Animals
  • Benz(a)Anthracenes*
  • Female
  • Mice
  • Mice, Inbred C3H
  • Microscopy, Electron
  • Ovarian Neoplasms / chemically induced*
  • Ovarian Neoplasms / pathology
  • Ovarian Neoplasms / ultrastructure

Substances

  • Benz(a)Anthracenes
  • 9,10-Dimethyl-1,2-benzanthracene