Anti-viral immunity: spotting virus-specific T cells

Curr Biol. 1998 Jul 2;8(14):R498-501. doi: 10.1016/s0960-9822(98)70317-3.

Abstract

Historically, quantitation of virus-specific CD8+ T cells has been accomplished by limiting dilution analysis of cytotoxic precursor cells. Recent studies have shown that this technique greatly underestimates the actual number of antigen-specific cells and have provided new insight into anti-viral immune responses.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / virology*
  • Cytotoxicity, Immunologic
  • Humans
  • Major Histocompatibility Complex
  • Receptors, Antigen, T-Cell / immunology
  • Virus Diseases / immunology
  • Viruses / immunology*

Substances

  • Receptors, Antigen, T-Cell