Abstract
Historically, quantitation of virus-specific CD8+ T cells has been accomplished by limiting dilution analysis of cytotoxic precursor cells. Recent studies have shown that this technique greatly underestimates the actual number of antigen-specific cells and have provided new insight into anti-viral immune responses.
MeSH terms
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Animals
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B-Lymphocytes / immunology
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CD8-Positive T-Lymphocytes / immunology*
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CD8-Positive T-Lymphocytes / virology*
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Cytotoxicity, Immunologic
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Humans
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Major Histocompatibility Complex
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Receptors, Antigen, T-Cell / immunology
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Virus Diseases / immunology
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Viruses / immunology*
Substances
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Receptors, Antigen, T-Cell