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Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment.
Acúrcio RC, Pozzi S, Carreira B, Pojo M, Gómez-Cebrián N, Casimiro S, Fernandes A, Barateiro A, Farricha V, Brito J, Leandro AP, Salvador JAR, Graça L, Puchades-Carrasco L, Costa L, Satchi-Fainaro R, Guedes RC, Florindo HF. Acúrcio RC, et al. J Immunother Cancer. 2022 Jul;10(7):e004695. doi: 10.1136/jitc-2022-004695. J Immunother Cancer. 2022. PMID: 35863821 Free PMC article.
Immune-mediated approaches against COVID-19.
Florindo HF, Kleiner R, Vaskovich-Koubi D, Acúrcio RC, Carreira B, Yeini E, Tiram G, Liubomirski Y, Satchi-Fainaro R. Florindo HF, et al. Among authors: acurcio rc. Nat Nanotechnol. 2020 Aug;15(8):630-645. doi: 10.1038/s41565-020-0732-3. Epub 2020 Jul 13. Nat Nanotechnol. 2020. PMID: 32661375 Free PMC article. Review.
Current hurdles to the translation of nanomedicines from bench to the clinic.
Đorđević S, Gonzalez MM, Conejos-Sánchez I, Carreira B, Pozzi S, Acúrcio RC, Satchi-Fainaro R, Florindo HF, Vicent MJ. Đorđević S, et al. Among authors: acurcio rc. Drug Deliv Transl Res. 2022 Mar;12(3):500-525. doi: 10.1007/s13346-021-01024-2. Epub 2021 Jul 23. Drug Deliv Transl Res. 2022. PMID: 34302274 Free PMC article. Review.
Preclinical models and technologies to advance nanovaccine development.
Peres C, Matos AI, Moura LIF, Acúrcio RC, Carreira B, Pozzi S, Vaskovich-Koubi D, Kleiner R, Satchi-Fainaro R, Florindo HF. Peres C, et al. Among authors: acurcio rc. Adv Drug Deliv Rev. 2021 May;172:148-182. doi: 10.1016/j.addr.2021.03.001. Epub 2021 Mar 9. Adv Drug Deliv Rev. 2021. PMID: 33711401 Review.
Polyoxazoline-Based Nanovaccine Synergizes with Tumor-Associated Macrophage Targeting and Anti-PD-1 Immunotherapy against Solid Tumors.
Matos AI, Peres C, Carreira B, Moura LIF, Acúrcio RC, Vogel T, Wegener E, Ribeiro F, Afonso MB, Santos FMF, Martínez-Barriocanal Á, Arango D, Viana AS, Góis PMP, Silva LC, Rodrigues CMP, Graca L, Jordan R, Satchi-Fainaro R, Florindo HF. Matos AI, et al. Among authors: acurcio rc. Adv Sci (Weinh). 2023 Sep;10(25):e2300299. doi: 10.1002/advs.202300299. Epub 2023 Jul 11. Adv Sci (Weinh). 2023. PMID: 37434063 Free PMC article.
Brain endothelial STING1 activation by Plasmodium-sequestered heme promotes cerebral malaria via type I IFN response.
Pais TF, Ali H, Moreira da Silva J, Duarte N, Neres R, Chhatbar C, Acúrcio RC, Guedes RC, Strano Moraes MC, Costa-Silva B, Kalinke U, Penha-Gonçalves C. Pais TF, et al. Among authors: acurcio rc. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2206327119. doi: 10.1073/pnas.2206327119. Epub 2022 Aug 29. Proc Natl Acad Sci U S A. 2022. PMID: 36037380 Free PMC article.