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NKG2D signaling on CD8⁺ T cells represses T-bet and rescues CD4-unhelped CD8⁺ T cell memory recall but not effector responses.
Zloza A, Kohlhapp FJ, Lyons GE, Schenkel JM, Moore TV, Lacek AT, O'Sullivan JA, Varanasi V, Williams JW, Jagoda MC, Bellavance EC, Marzo AL, Thomas PG, Zafirova B, Polić B, Al-Harthi L, Sperling AI, Guevara-Patiño JA. Zloza A, et al. Among authors: jagoda mc. Nat Med. 2012 Feb 26;18(3):422-8. doi: 10.1038/nm.2683. Nat Med. 2012. PMID: 22366950 Free PMC article.
Development of tumor-infiltrating CD8+ T cell memory precursor effector cells and antimelanoma memory responses are the result of vaccination and TGF-β blockade during the perioperative period of tumor resection.
Bellavance EC, Kohlhapp FJ, Zloza A, O'Sullivan JA, McCracken J, Jagoda MC, Lacek AT, Posner MC, Guevara-Patino JA. Bellavance EC, et al. Among authors: jagoda mc. J Immunol. 2011 Mar 15;186(6):3309-16. doi: 10.4049/jimmunol.1002549. Epub 2011 Feb 2. J Immunol. 2011. PMID: 21289306 Free PMC article.