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Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment.
Poznanski SM, Singh K, Ritchie TM, Aguiar JA, Fan IY, Portillo AL, Rojas EA, Vahedi F, El-Sayes A, Xing S, Butcher M, Lu Y, Doxey AC, Schertzer JD, Hirte HW, Ashkar AA. Poznanski SM, et al. Among authors: ritchie tm. Cell Metab. 2021 Jun 1;33(6):1205-1220.e5. doi: 10.1016/j.cmet.2021.03.023. Epub 2021 Apr 13. Cell Metab. 2021. PMID: 33852875 Free article.
Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection.
Lee AJ, Feng E, Chew MV, Balint E, Poznanski SM, Giles E, Zhang A, Marzok A, Revill SD, Vahedi F, Dubey A, Ayaub E, Jimenez-Saiz R, McGrath JJC, Ritchie TM, Jordana M, Jonigk DD, Ackermann M, Ask K, Miller M, Richards CD, Ashkar AA. Lee AJ, et al. Among authors: ritchie tm. PLoS Pathog. 2022 May 5;18(5):e1010471. doi: 10.1371/journal.ppat.1010471. eCollection 2022 May. PLoS Pathog. 2022. PMID: 35512020 Free PMC article.
Expanded human NK cells armed with CAR uncouple potent anti-tumor activity from off-tumor toxicity against solid tumors.
Portillo AL, Hogg R, Poznanski SM, Rojas EA, Cashell NJ, Hammill JA, Chew MV, Shenouda MM, Ritchie TM, Cao QT, Hirota JA, Dhesy-Thind S, Bramson JL, Ashkar AA. Portillo AL, et al. Among authors: ritchie tm. iScience. 2021 May 24;24(6):102619. doi: 10.1016/j.isci.2021.102619. eCollection 2021 Jun 25. iScience. 2021. PMID: 34159300 Free PMC article.