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BYON4228 is a pan-allelic antagonistic SIRPα antibody that potentiates destruction of antibody-opsonized tumor cells and lacks binding to SIRPγ on T cells.
J Immunother Cancer. 2023 Apr;11(4):e006567. doi: 10.1136/jitc-2022-006567.
J Immunother Cancer. 2023.
PMID: 37068796
Free PMC article.
Discovery of SYD5115, a novel orally active small molecule TSH-R antagonist.
Karstens WFJ, M B P Menge W, Martens G, Op Het Veld SJN, Th H van Eupen J, Demon M, van Achterberg TAE, Arisse-Thijssen MJ, Santegoeds-Lenssen EWH, van der Lee MMC, Ubink R, Arends RJ, Sesink A, Blomenröhr M, Marco Timmers C.
Karstens WFJ, et al. Among authors: santegoeds lenssen ewh.
Bioorg Med Chem. 2023 Apr 15;84:117258. doi: 10.1016/j.bmc.2023.117258. Epub 2023 Mar 23.
Bioorg Med Chem. 2023.
PMID: 37001244
Free article.
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