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iPSC-derived natural killer cells expressing the FcγR fusion CD64/16A can be armed with antibodies for multitumor antigen targeting.
Snyder KM, Dixon KJ, Davis Z, Hosking M, Hart G, Khaw M, Matson A, Bjordahl R, Hancock B, Shirinbak S, Miller JS, Valamehr B, Wu J, Walcheck B. Snyder KM, et al. Among authors: shirinbak s. J Immunother Cancer. 2023 Dec 6;11(12):e007280. doi: 10.1136/jitc-2023-007280. J Immunother Cancer. 2023. PMID: 38056893 Free PMC article.
Combined immune checkpoint blockade increases CD8+CD28+PD-1+ effector T cells and provides a therapeutic strategy for patients with neuroblastoma.
Shirinbak S, Chan RY, Shahani S, Muthugounder S, Kennedy R, Hung LT, Fernandez GE, Hadjidaniel MD, Moghimi B, Sheard MA, Epstein AL, Fabbri M, Shimada H, Asgharzadeh S. Shirinbak S, et al. Oncoimmunology. 2021 Jan 4;10(1):1838140. doi: 10.1080/2162402X.2020.1838140. Oncoimmunology. 2021. PMID: 33489468 Free PMC article.
Tumor-associated macrophages promote neuroblastoma via STAT3 phosphorylation and up-regulation of c-MYC.
Hadjidaniel MD, Muthugounder S, Hung LT, Sheard MA, Shirinbak S, Chan RY, Nakata R, Borriello L, Malvar J, Kennedy RJ, Iwakura H, Akamizu T, Sposto R, Shimada H, DeClerck YA, Asgharzadeh S. Hadjidaniel MD, et al. Among authors: shirinbak s. Oncotarget. 2017 Sep 16;8(53):91516-91529. doi: 10.18632/oncotarget.21066. eCollection 2017 Oct 31. Oncotarget. 2017. PMID: 29207662 Free PMC article.