Background Gastrointestinal (GI) cancers are the most common human tumors encountered
worldwide. The majority of GI cancers are unresectable at the time of diagnosis, and in the …

Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown activity in
melanoma, but has not been previously evaluated in metastatic non-small cell lung cancer …

Purpose Nivolumab, a human immunoglobulin G 4–blocking antibody against the T-cell
programmed death-1 checkpoint protein, has activity against metastatic melanoma. Its …

PURPOSE Effective treatment options are limited for patients with advanced (metastatic or
unresectable) melanoma who progress after immune checkpoint inhibitors and targeted …

Highlights•High-throughput screening (HTS) facilitates selection of the best performing
strain.•Biosensor-enabled HTS obviates the need for sophisticated analytical …

Studies of Wnt activation in gastric cancer have yielded conflicting results. The goals of this
study were to determine the frequency of Wnt pathway activation and β-catenin mutation in …

Expression of PD-1 ligands by tumors and interaction with PD-1–expressing T cells in the
tumor microenvironment can result in tolerance. Therapies targeting this coinhibitory axis …

Two major populations of myeloid-derived suppressor cells (MDSCs), monocytic MDSCs (M-
MDSCs) and polymorphonuclear MDSCs (PMN-MDSCs) regulate immune responses in …

Background Surgery is currently the primary treatment modality for metastatic mela-noma
involving the inguinal lymph nodes. However, inguinal lymph node dissections are …

Purpose: To determine safety and feasibility of adjuvant ipilimumab following resection of
high-risk melanoma and to identify surrogate markers for benefit. Experimental Design: In …