[HTML][HTML] Multimodality analysis confers a prognostic benefit of a T-cell infiltrated tumor microenvironment and peripheral immune status in patients with melanoma

GM Beasley, MC Brown, NE Farrow… - … for ImmunoTherapy of …, 2022 - ncbi.nlm.nih.gov
Background We previously reported results from a phase 1 study testing intratumoral
recombinant poliovirus, lerapolturev, in 12 melanoma patients. All 12 patients received anti …

[HTML][HTML] Spatial biology analysis reveals B cell follicles in secondary lymphoid structures may regulate anti-tumor responses at initial melanoma diagnosis

AD Therien, GM Beasley, KE Rhodin… - Frontiers in …, 2022 - frontiersin.org
Introduction B cells are key regulators of immune responses in melanoma. We aimed to
explore differences in the histologic location and activation status of B cell follicles in …

Dissecting the immune landscape of tumor draining lymph nodes in melanoma with high-plex spatially resolved protein detection

GM Beasley, AD Therien, EK Holl, R Al-Rohil… - Cancer Immunology …, 2021 - Springer
Background In melanoma patients, microscopic tumor in the sentinel lymph-node biopsy
(SLN) increases the risk of distant metastases, but the transition from tumor in the SLN to …

[CITATION][C] Spatial Biology Analysis Reveals the Location and Activation of B Cells in Sentinel Lymph Nodes Correlate with Prognosis in Melanoma Patients

AD Therien, EK Holl, R Al-Rohil… - ANNALS OF …, 2022 - SPRINGER ONE NEW YORK …