Molecular analysis of the association of HLA-B53 and resistance to severe malaria
AVS Hill, J Elvin, AC Willis, M Aidoo, CEM Allsopp… - Nature, 1992 - nature.com
The protective association between the human leukocyte antigen HLA-B53 and severe
malaria was investigated by sequencing of peptides eluted from this molecule followed by …
malaria was investigated by sequencing of peptides eluted from this molecule followed by …
The immunogenetics of human infectious diseases
AVS Hill - Annual review of immunology, 1998 - annualreviews.org
▪ Abstract Twin and adoptee studies have indicated that host genetic factors are major
determinants of susceptibility to infectious diseases in humans. Twin studies have also …
determinants of susceptibility to infectious diseases in humans. Twin studies have also …
Genetics of susceptibitlity to human infectious disease
Abstract Before Robert Koch's work in the late nineteenth century, diseases such as
tuberculosis and leprosy were widely believed to be inherited disorders. Heritability of …
tuberculosis and leprosy were widely believed to be inherited disorders. Heritability of …
[HTML][HTML] Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South …
Background A safe and efficacious vaccine against severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control …
coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control …
[HTML][HTML] Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled …
Background The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) might be curtailed by vaccination. We assessed the safety, reactogenicity, and …
2) might be curtailed by vaccination. We assessed the safety, reactogenicity, and …
[HTML][HTML] Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a …
Summary Background The ChAdOx1 nCoV-19 (AZD1222) vaccine has been approved for
emergency use by the UK regulatory authority, Medicines and Healthcare products …
emergency use by the UK regulatory authority, Medicines and Healthcare products …
[HTML][HTML] Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind …
MN Ramasamy, AM Minassian, KJ Ewer, AL Flaxman… - The Lancet, 2020 - thelancet.com
Background Older adults (aged≥ 70 years) are at increased risk of severe disease and
death if they develop COVID-19 and are therefore a priority for immunisation should an …
death if they develop COVID-19 and are therefore a priority for immunisation should an …
Common West African HLA antigens are associated with protection from severe malaria
A large case-control study of malaria in West African children shows that a human leucocyte
class I antigen (HLA-Bw53) and an HLA class II haplotype (DRB1* 1302–DQB1* 0501) …
class I antigen (HLA-Bw53) and an HLA class II haplotype (DRB1* 1302–DQB1* 0501) …
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
S Nejentsev, JMM Howson, NM Walker, J Szeszko… - Nature, 2007 - nature.com
The major histocompatibility complex (MHC) on chromosome 6 is associated with
susceptibility to more common diseases than any other region of the human genome …
susceptibility to more common diseases than any other region of the human genome …
[HTML][HTML] Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B. 1.1. 7): an exploratory analysis of a randomised …
Background A new variant of SARS-CoV-2, B. 1.1. 7, emerged as the dominant cause of
COVID-19 disease in the UK from November, 2020. We report a post-hoc analysis of the …
COVID-19 disease in the UK from November, 2020. We report a post-hoc analysis of the …