User profiles for "author:Alan Parker"

Alan Parker

Rational Formulation
Verified email at rationalformulation.com
Cited by 2485

The effects of solvation on the properties of anions in dipolar aprotic solvents

AJ Parker - Quarterly Reviews, Chemical Society, 1962 - pubs.rsc.org
CHEMISTS need an understanding of the behaviour of ions in solution and it should be
emphasised that the chemistry of anions in dipolar aprotic solvents differs greatly from their …

Tropism-modification strategies for targeted gene delivery using adenoviral vectors

L Coughlan, R Alba, AL Parker, AC Bradshaw… - Viruses, 2010 - mdpi.com
Achieving high efficiency, targeted gene delivery with adenoviral vectors is a long-standing
goal in the field of clinical gene therapy. To achieve this, platform vectors must combine …

Protic-dipolar aprotic solvent effects on rates of bimolecular reactions

AJ Parker - Chemical Reviews, 1969 - ACS Publications
Bimolecular reactions (see eq 1 below) between anions and uncharged species, as well as
some bimolecular reactions of other charge types, are often very much faster in dipolar …

Nonviral gene delivery: techniques and implications for molecular medicine

AL Parker, C Newman, S Briggs, L Seymour… - Expert reviews in …, 2003 - cambridge.org
Medical research continues to illuminate the origins of many human diseases. Gene therapy
has been widely proposed as a novel strategy by which this knowledge can be used to …

[HTML][HTML] Adenovirus serotype 5 hexon mediates liver gene transfer

SN Waddington, JH McVey, D Bhella, AL Parker… - Cell, 2008 - cell.com
Adenoviruses are used extensively as gene transfer agents, both experimentally and
clinically. However, targeting of liver cells by adenoviruses compromises their potential …

ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome

AT Baker, RJ Boyd, D Sarkar, A Teijeira-Crespo… - Science …, 2021 - science.org
Vaccines derived from chimpanzee adenovirus Y25 (ChAdOx1), human adenovirus type 26
(HAdV-D26), and human adenovirus type 5 (HAdV-C5) are critical in combatting the severe …

The scission of the sulfur-sulfur bond

AJ Parker, N Kharasch - Chemical Reviews, 1959 - ACS Publications
The objectives of this review are:(1) to note the major current interests in the scission of the
sulfur-sulfur bond;(2) to summarize and exemplify the classes of organic compounds that …

Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes

AL Parker, SN Waddington, CG Nicol… - Blood, 2006 - ashpublications.org
Upon local delivery, adenovirus (Ad) serotype 5 viruses use the coxsackie and Ad receptor
(CAR) for cell binding and αv integrins for internalization. When administered systemically …

Laterally stabilized complexes of DNA with linear reducible polycations: strategy for triggered intracellular activation of DNA delivery vectors

D Oupickı, AL Parker, LW Seymour - Journal of the American …, 2002 - ACS Publications
Target-specific DNA delivery requires vectors that combine stability in the biological milieu,
receptor-mediated uptake into target cells, and intracellular activation to mediate transgene …

Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

MD Crowther, G Dolton, M Legut, ME Caillaud… - Nature …, 2020 - nature.com
Human leukocyte antigen (HLA)-independent, T cell–mediated targeting of cancer cells
would allow immune destruction of malignancies in all individuals. Here, we use genome …