Chemokines are proteins which induce chemotaxis, promote differentiation of immune cells,
and cause tissue extravasation. Given these properties, their role in anti-tumor immune …

Epstein-Barr virus associated gastric cancer (EBVaGC) comprises approximately 10% of
gastric carcinomas. Multiple factors contribute to tumorigenesis, including EBV driven …

B cells are recognized as the main effector cells of humoral immunity which suppress tumor
progression by secreting immunoglobulins, promoting T cell response, and killing cancer …

The efficacy of immunotherapy varies widely among different gastrointestinal cancers.
Response to immune checkpoint inhibitors is shown to correlate with tumor mutation load …

Background Gastroesophageal cancers are often grouped together even though cancers
that originate in the esophagus often exhibit different histological features, geographical …

Microsatellite instability‐high (MSI‐H) and tumor mutational burden (TMB) are predictive
biomarkers for immune‐checkpoint inhibitors (ICIs). Still, the relationship between the …

PURPOSE Promising single-agent activity from sotorasib and adagrasib in KRAS G12C-
mutant tumors has provided clinical evidence of effective KRAS signaling inhibition …

Purpose: GEP-NENs are rare malignancies with increasing incidence. Their molecular
characteristics are still undefined. We explored the underlying biology of GEP-NENs and the …

The role of aberrant hepatocyte growth factor receptor (c-MET, also known as tyrosine-
protein kinase MET)/hepatocyte growth factor (HGF) signaling in cancer progression and …

Introduction Prognosis of biliary tract cancers (BTC) remains dismal and novel treatment
strategies are needed to improve survival. BRCA mutations are known to occur in BTC but …