Lung cancer is the leading cause of cancer-related mortality not only in the United States but
also around the world. In North America, lung cancer has become more predominant among …

Apoptosis, or programmed cell death, is a mechanism by which cells undergo death to
control cell proliferation or in response to DNA damage. The understanding of apoptosis has …

The Ras gene product is a monomeric membrane-localized G protein of 21 kd that functions
as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to …

Purpose: To review the pharmacodynamics, pharmacokinetics, toxicities, and relative
clinical activities of cisplatin and carboplatin. Through a search of the MEDLINE database …

Purpose This multicenter, open-label, phase II study was undertaken to assess the antitumor
activity and safety of the oral mitogen-activated extracellular signal regulated kinase kinase …

Phase I Pharmacokinetic and Pharmacodynamic Study of the Oral, Small-Molecule Mitogen-Activated
Protein Kinase Kinase 1/2 Inhibitor AZD6244 (ARRY-142886) in Patients With Advanced …

Small cell lung cancer accounts for approximately 15% of bronchogenic carcinomas. It is the
cancer most commonly associated with various paraneoplastic syndromes, including the …

Angiogenesis, or the formation of new capillary blood vessels, occurs primarily during
human development and reproduction; however, aberrant regulation of angiogenesis is also …

The views and recommendations made in this document do not represent the official
position of any publisher or professional medical society. This document has not been …

Study objectives To improve the current understanding of the etiology and natural history of
primary lung cancer, we need to study the dynamic changes of clinical presentation and …