The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting …

Immune mechanisms have evolved to cope with local entry of microbes acting in a confined
fashion but eventually inducing systemic immune memory. Indeed, in situ delivery of a …

CD137 (4‐1BB, TNF‐receptor superfamily 9) is a surface glycoprotein of the TNFR family
which can be induced on a variety of leukocyte subsets. On T and NK cells, CD137 is …

Weak and ineffective antitumor cytotoxic T lymphocyte (CTL) responses can be rescued by
immunomodulatory mAbs targeting PD-1 or CD137. Using Batf3−/− mice, which are …

Preclinical and clinical evidence indicate that the proimmune effects of radiotherapy can be
synergistically augmented with immunostimulatory mAbs to act both on irradiated tumor …

Retroviral gene transfer of interleukin-12 (IL-12) into T cells markedly enhances antitumor
efficacy upon adoptive transfer but has clinically shown unacceptable severe side effects. To …

Virotherapy and checkpoint inhibitors can be combined for the treatment of cancer with
complementarity and potential for synergistic effects. We have developed a cytolytic but …

Background The immune response to cancer is often conceptualized with the cancer
immunity cycle. An essential step in this interpretation is that antigens released by dying …

Multiple lines of evidence indicate a critical role of antigen cross-presentation by
conventional BATF3-dependent type 1 classical dendritic cells (cDC1) in CD8-mediated …

T and NK lymphocytes express CD137 (4-1BB), a costimulatory receptor of the TNFR family
whose function is exploitable for cancer immunotherapy. Mitochondria regulate the function …