Interleukin newcomers creating new numbers in rheumatology: IL-34 to IL-38

G Clavel, A Thiolat, MC Boissier - Joint bone spine, 2013 - Elsevier
The development of innovative technologies is steadily increasing the body of knowledge on
molecules involved in physiological functions. Thus, several interleukins (ILs) have been …

Radiation therapy for triple-negative breast cancer: Emerging role of microRNAs as biomarkers and radiosensitivity modifiers. A systematic review

NH To, HQ Nguyen, A Thiolat, B Liu, J Cohen… - Breast Cancer Research …, 2022 - Springer
Purpose Radiation therapy (RT) for triple-negative breast cancer (TNBC) treatment is
currently delivered in the adjuvant setting and is under investigation as a booster of …

The mouse dendritic cell marker CD11c is down-regulated upon cell activation through Toll-like receptor triggering

H Singh-Jasuja, A Thiolat, M Ribon, MC Boissier… - Immunobiology, 2013 - Elsevier
Dendritic cells (DC) play a key role in regulating immune responses and are the best
professional antigen-presenting cells. Two major DC populations are defined in part …

Control of GVHD by regulatory T cells depends on TNF produced by T cells and TNFR2 expressed by regulatory T cells

M Leclerc, S Naserian, C Pilon, A Thiolat… - Blood, The Journal …, 2016 - ashpublications.org
Abstract Therapeutic CD4+ Foxp3+ natural regulatory T cells (Tregs) can control
experimental graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell …

Targeting IL-6 for the treatment of rheumatoid arthritis: Phase II investigational drugs

L Semerano, A Thiolat, E Minichiello… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: IL-6 is a key cytokine in the pathogenesis of rheumatoid arthritis (RA). The
clinical efficacy of tocilizumab (TCZ), a humanized anti-IL6-receptor mAb, confirmed the …

Control of humoral response in renal transplantation by belatacept depends on a direct effect on B cells and impaired T follicular helper-B cell crosstalk

C Leibler, A Thiolat, C Hénique… - Journal of the …, 2018 - journals.lww.com
Generation of de novo donor-specific antibodies (dnDSAs) after renal transplant is
recognized as the leading cause of late transplant failure. Hence, the optimal …

[HTML][HTML] Simple, reproducible, and efficient clinical grading system for murine models of acute graft-versus-host disease

S Naserian, M Leclerc, A Thiolat, C Pilon… - Frontiers in …, 2018 - frontiersin.org
Acute graft-versus-host disease (aGVHD) represents a challenging complication after
allogeneic hematopoietic stem cell transplantation. Despite the intensive preclinical …

[HTML][HTML] CD8+ T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas

LL Niborski, P Gueguen, M Ye, A Thiolat… - Nature …, 2022 - nature.com
Tumor-infiltrating CD8+ T cells progressively lose functionality and fail to reject tumors. The
underlying mechanism and re-programing induced by checkpoint blockers are incompletely …

In vivo expansion of activated Foxp3+ regulatory T cells and establishment of a type 2 immune response upon IL-33 treatment protect against experimental arthritis

J Biton, S Khaleghparast Athari, A Thiolat… - The Journal of …, 2016 - journals.aai.org
IL-33 is strongly involved in several inflammatory and autoimmune disorders with both pro-
and anti-inflammatory properties. However, its contribution to chronic autoimmune …

[HTML][HTML] Macrophage autophagy protects against hepatocellular carcinogenesis in mice

A Deust, MN Chobert, V Demontant, G Gricourt… - Scientific Reports, 2021 - nature.com
Autophagy is a lysosomal degradation pathway of cellular components that regulates
macrophage properties. Macrophages are critically involved in tumor growth, metastasis …