T-regulatory cells (Tregs) are found infiltrating tumors in a vast array of tumor types, and
tumor-infiltrating Tregs are often associated with a poor clinical outcome. Tregs are potent …

Although immune mechanisms can suppress tumour growth,, tumours establish potent,
overlapping mechanisms that mediate immune evasion,,,. Emerging evidence suggests a …

An essential advantage during eukaryotic cell evolution was the acquisition of a network of
mitochondria as a source of energy for cell metabolism and contrary to conventional …

Angiogenesis is a hallmark of cancer and a requisite that tumors must achieve to fulfill their
metabolic needs of nutrients and oxygen. As a critical step in cancer progression, the …

Anti-CD19 chimeric antigen receptor (CAR) T cell therapy has led to unprecedented
responses in patients with high-risk hematologic malignancies. However, up to 60% of …

In spite of their having sufficient immunogenicity, tumor vaccines remain largely ineffective.
The mechanisms underlying this lack of efficacy are still unclear. Here we report a previously …

We investigated the role of chemokines in regulating T cell accumulation in solid tumors.
CCL5 and CXCL9 overexpression was associated with CD8+ T cell infiltration in solid …

Alterations in gut microbiota impact the pathophysiology of several diseases, including
cancer. Radiotherapy (RT), an established curative and palliative cancer treatment, exerts …

Adoptive T cell therapy (ACT) is a promising new modality for malignancies. Here, we report
that adoptive T cell efficacy in tumor-bearing mice is significantly affected by differences in …

BACKGROUND: The aim of the study was to determine whether tumor‐infiltrating
lymphocytes and/or tumor mitotic activity could identify subgroups of patients with advanced …