Cancer cells (vs. normal cells) demonstrate evidence of oxidative stress, increased
glycolysis, and increased pentose cycle activity. The oxidative stress in cancer cells has …

Glucose deprivation has been hypothesized to cause cytotoxicity by inducing metabolic
oxidative stress in human cancer cells. The current work tests the hypothesis that 2-deoxy-d …

A study was conducted in hamsters to determine if group B soyasaponins improve plasma
cholesterol status by increasing the excretion of fecal bile acids and neutral sterols, to …

The relationship between chemical structure and gut microbial degradation rates of 14
flavonoids, flavone, apigenin, chrysin, naringenin, kaempferol, genistein, daidzein, daidzin …

Increased glutathione (GSH) and thioredoxin (Trx) metabolism are mechanisms that are
widely implicated in resistance of cancer cells to chemotherapy. The current study …

Redox regulation of epidermal growth factor receptor (EGFR) signaling helps protect cells
against oxidative stress. In this study, we investigated whether the cytotoxicity of an EGFR …

Increasing evidence suggests that cancer cells (relative to normal cells) have altered
mitochondrial electron transport chains (ETC) that are more likely to form reactive oxygen …

Despite the role of epidermal growth factor receptor (EGFR) signaling in head and neck
squamous cell carcinoma (HNSCC) development and progression, clinical trials involving …

Most head and neck squamous cell carcinomas (HNSCCs) overexpress epidermal growth
factor receptor (EGFR) and EGFR inhibitors are routinely used in the treatment of HNSCC …

Erlotinib has demonstrated poor clinical response rates for head and neck squamous cell
carcinoma (HNSCC) to date and the majority of respondents acquire resistance to erlotinib …