A growing number of studies have shown that γδ T cells play a pivotal role in mediating the
clearance of tumors and pathogen-infected cells with their potent cytotoxic, cytolytic, and …

Melanoma of the skin is a common cancer only in Europeans, whereas it arises in internal
body surfaces (mucosal sites) and on the hands and feet (acral sites) in people throughout …

Cancer cells exploit the expression of the programmed death-1 (PD-1) ligand 1 (PD-L1) to
subvert T-cell-mediated immunosurveillance,. The success of therapies that disrupt PD-L1 …

INTRODUCTION T cells represent a key component of the immune system that can
recognize foreign molecules (antigens) via cognate cell surface receptors termed T cell …

Group 2 innate lymphoid cells (ILC2s) are essential to maintain tissue homeostasis. In
cancer, ILC2s can harbor both pro-tumorigenic and anti-tumorigenic functions, but we know …

Importance Biliary tract cancers represent a rare group of malignant conditions with very
limited treatment options. Patients with advanced disease have a poor outcome with current …

Natural killer (NK) cell activity is essential for initiating antitumor responses and may be
linked to immunotherapy success. NK cells and other innate immune components could be …

Purpose: Combination immunotherapy with anti–CTLA-4 and anti–PD-1 blockade has
demonstrated significant clinical activity across several tumor types. Neuroendocrine tumors …

Malignant melanoma is one of the most difficult cancers to treat due to its resistance to
chemotherapy. Despite recent successes with BRAF inhibitors and immune checkpoint …

We assessed the utility of droplet digital PCR (ddPCR) to evaluate the potential of using
circulating tumour DNA (ctDNA) as a post therapy monitoring tool in melanoma by …