The tipping point for combination therapy: cancer vaccines with radiation, chemotherapy, or targeted small molecule inhibitors
Therapeutic cancer vaccines are a unique treatment modality in that they initiate a dynamic
process of activating the host immune system, which can then be exploited by concurrent or …
process of activating the host immune system, which can then be exploited by concurrent or …
[HTML][HTML] Immune consequences of tyrosine kinase inhibitors that synergize with cancer immunotherapy
AR Kwilas, RN Donahue, KY Tsang… - Cancer cell & …, 2015 - ncbi.nlm.nih.gov
Combination therapy for the treatment of cancer is becoming increasingly essential as we
gain improved understanding of the complexity of cancer progression and the mechanisms …
gain improved understanding of the complexity of cancer progression and the mechanisms …
[HTML][HTML] In the field: exploiting the untapped potential of immunogenic modulation by radiation in combination with immunotherapy for the treatment of cancer
AR Kwilas, RN Donahue, MB Bernstein… - Frontiers in …, 2012 - frontiersin.org
Radiation has long been the standard of care for many types of cancer. It is employed to
locally eradicate tumor cells as well as alter tumor stroma with either curative or palliative …
locally eradicate tumor cells as well as alter tumor stroma with either curative or palliative …
[HTML][HTML] Dual effects of a targeted small-molecule inhibitor (cabozantinib) on immune-mediated killing of tumor cells and immune tumor microenvironment …
AR Kwilas, A Ardiani, RN Donahue, DT Aftab… - Journal of translational …, 2014 - Springer
Background Growing awareness of the complexity of carcinogenesis has made multimodal
therapies for cancer increasingly compelling and relevant. In recent years, immunotherapy …
therapies for cancer increasingly compelling and relevant. In recent years, immunotherapy …
[HTML][HTML] IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ …
PS Kim, AR Kwilas, W Xu, S Alter, EK Jeng, HC Wong… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract Interleukin (IL)-15-N72D superagonist-complexed with IL-15RαSushi-Fc fusion
protein (IL-15SA/IL-15RαSu-Fc; ALT-803) has been reported to exhibit significant anti-tumor …
protein (IL-15SA/IL-15RαSu-Fc; ALT-803) has been reported to exhibit significant anti-tumor …
[HTML][HTML] The IDO1 selective inhibitor epacadostat enhances dendritic cell immunogenicity and lytic ability of tumor antigen-specific T cells
C Jochems, M Fantini, RI Fernando, AR Kwilas… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Epacadostat is a novel inhibitor of indoleamine-2, 3-dioxygenase-1 (IDO1) that suppresses
systemic tryptophan catabolism and is currently being evaluated in ongoing clinical trials …
systemic tryptophan catabolism and is currently being evaluated in ongoing clinical trials …
[HTML][HTML] Androgen deprivation therapy sensitizes prostate cancer cells to T-cell killing through androgen receptor dependent modulation of the apoptotic pathway
A Ardiani, SR Gameiro, AR Kwilas, RN Donahue… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Despite recent advances in diagnosis and management, prostrate cancer remains the
second most common cause of death from cancer in American men, after lung cancer …
second most common cause of death from cancer in American men, after lung cancer …
[HTML][HTML] Androgen deprivation therapy sensitizes triple negative breast cancer cells to immune-mediated lysis through androgen receptor independent modulation of …
AR Kwilas, A Ardiani, SR Gameiro, J Richards… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Among breast cancer types, triple-negative breast cancer (TNBC) has the fewest treatment
options and the lowest 5-year survival rate. Androgen receptor (AR) inhibition has displayed …
options and the lowest 5-year survival rate. Androgen receptor (AR) inhibition has displayed …
[HTML][HTML] A poxviral-based cancer vaccine targeting the transcription factor twist inhibits primary tumor growth and metastases in a model of metastatic breast cancer …
AR Kwilas, A Ardiani, U Dirmeier, C Wottawah… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Several transcription factors play a role in the alteration of gene expression that occurs
during cancer metastasis. Twist expression has been shown to be associated with the …
during cancer metastasis. Twist expression has been shown to be associated with the …
Respiratory syncytial virus engineered to express the cystic fibrosis transmembrane conductance regulator corrects the bioelectric phenotype of human cystic fibrosis …
AR Kwilas, MA Yednak, L Zhang, R Liesman… - Journal of …, 2010 - Am Soc Microbiol
Cystic fibrosis (CF) is the most common lethal recessive genetic disease in the Caucasian
population. It is caused by mutations in the CF transmembrane conductance regulator …
population. It is caused by mutations in the CF transmembrane conductance regulator …