User profiles for "author:Annacarolina Da Silva"

Annacarolina da Silva

Weill Cornell Medicine/NewYork Presbyterian Hospital
Verified email at med.cornell.edu
Cited by 3682

Real-time genomic characterization of advanced pancreatic cancer to enable precision medicine

AJ Aguirre, JA Nowak, ND Camarda, RA Moffitt… - Cancer discovery, 2018 - AACR
Clinically relevant subtypes exist for pancreatic ductal adenocarcinoma (PDAC), but
molecular characterization is not yet standard in clinical care. We implemented a biopsy …

Fusobacterium nucleatumin Colorectal Carcinoma Tissue According to Tumor Location

K Mima, Y Cao, AT Chan, ZR Qian… - Clinical and …, 2016 - journals.lww.com
OBJECTIVES: Evidence suggests a possible role ofFusobacterium nucleatumin colorectal
carcinogenesis, especially in right-sided proximal colorectum. Considering a change in …

Tumour CD274 (PD-L1) expression and T cells in colorectal cancer

Y Masugi, R Nishihara, J Yang, K Mima, A Da Silva… - Gut, 2017 - gut.bmj.com
Objective Evidence suggests that CD274 (programmed death-ligand 1, B7-H1) immune
checkpoint ligand repress antitumour immunity through its interaction with the PDCD1 …

Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer

MB Yurgelun, AB Chittenden, V Morales-Oyarvide… - Genetics in …, 2019 - nature.com
Purpose Germline variants in double-strand DNA damage repair (dsDDR) genes (eg,
BRCA1/2) predispose to pancreatic adenocarcinoma (PDAC) and may predict sensitivity to …

Leukocyte heterogeneity in pancreatic ductal adenocarcinoma: phenotypic and spatial features associated with clinical outcome

SM Liudahl, CB Betts, S Sivagnanam… - Cancer discovery, 2021 - AACR
Immunotherapies targeting aspects of T cell functionality are efficacious in many solid
tumors, but pancreatic ductal adenocarcinoma (PDAC) remains refractory to these …

Association of alterations in main driver genes with outcomes of patients with resected pancreatic ductal adenocarcinoma

ZR Qian, DA Rubinson, JA Nowak… - JAMA …, 2018 - jamanetwork.com
Importance Although patients with resected pancreatic adenocarcinoma are at high risk for
disease recurrence, few biomarkers are available to inform patient outcomes. Objective To …

The prognostic role of macrophage polarization in the colorectal cancer microenvironment

JP Väyrynen, K Haruki, MC Lau, SA Väyrynen… - Cancer immunology …, 2021 - AACR
Macrophages are among the most common cells in the colorectal cancer microenvironment,
but their prognostic significance is incompletely understood. Using multiplexed …

Dietary patterns and risk of colorectal cancer: analysis by tumor location and molecular subtypes

RS Mehta, M Song, R Nishihara, DA Drew, K Wu… - Gastroenterology, 2017 - Elsevier
Background & Aims Western and prudent dietary patterns have been associated with higher
and lower risks of colorectal cancer (CRC), respectively. However, little is known about the …

Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors

P Cejas, Y Drier, KMA Dreijerink, LAA Brosens… - Nature medicine, 2019 - nature.com
Most pancreatic neuroendocrine tumors (PNETs) do not produce excess hormones and are
therefore considered 'non-functional',–. As clinical behaviors vary widely and distant …

Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status

T Hamada, X Zhang, K Mima, S Bullman… - Cancer immunology …, 2018 - AACR
The presence of Fusobacterium nucleatum (F. nucleatum) in colorectal carcinoma tissue has
been associated with microsatellite instability (MSI), lower-level T-cell infiltrates, and poor …