Fanconi anemia (FA) is a complex genetic disorder characterized by bone marrow failure
(BMF), congenital defects, inability to repair DNA interstrand cross-links (ICLs), and cancer …

Adult-type granulosa cell tumor is a clinically and molecularly unique subtype of ovarian
cancer. These tumors originate from the sex cord stromal cells of the ovary and represent 3 …

Importance Patients with recurrent ovarian carcinoma frequently develop resistance to
platinum-based chemotherapy, at which time treatment options become limited. Objective To …

DNA polymerase theta (POLθ or POLQ) is synthetic lethal with homologous recombination
(HR) deficiency and is thus a candidate target for HR-deficient cancers. Through high …

Background High-grade serous ovarian cancers show increased replication stress,
rendering cells vulnerable to ATR inhibition because of near universal loss of the G1/S …

Combined PARP and immune checkpoint inhibition has yielded encouraging results in
ovarian cancer, but predictive biomarkers are lacking. We performed immunogenomic …

The mechanisms regulating exhaustion of tumor-infiltrating lymphocytes (TIL) and
responsiveness to PD-1 blockade remain partly unknown. In human ovarian cancer, we …

The development of single-cell and spatial technologies has enabled a more detailed
understanding of the tumor microenvironment and its role in therapy response and clinical …

Purpose: PARP inhibitors are approved for the treatment of high-grade serous ovarian
cancers (HGSOC). Therapeutic resistance, resulting from restoration of homologous …

In a trial of patients with high grade serous ovarian cancer (HGSOC), addition of the ATR
inhibitor berzosertib to gemcitabine improved progression free survival (PFS) compared to …