Impact of tumor microenvironment on adoptive T cell transfer activity

C Martín-Otal, F Navarro, N Casares… - International Review of …, 2022 - Elsevier
Recent advances in immunotherapy have revolutionized the treatment of cancer. The use of
adoptive cell therapies (ACT) such as those based on tumor infiltrating lymphocytes (TILs) or …

[HTML][HTML] Intratumoral electroporation of a self-amplifying RNA expressing IL-12 induces antitumor effects in mouse models of cancer

N Silva-Pilipich, A Lasarte-Cía, T Lozano… - … Therapy-Nucleic Acids, 2022 - cell.com
Alphavirus vectors based on self-amplifying RNA (saRNA) generate high and transient
levels of transgene expression and induce innate immune responses, making them an …

[HTML][HTML] Improvement of cognitive function in wild-type and Alzheimer s disease mouse models by the immunomodulatory properties of menthol inhalation or by …

N Casares, M Alfaro, M Cuadrado-Tejedor… - Frontiers in …, 2023 - frontiersin.org
A complex network of interactions exists between the olfactory, immune and central nervous
systems. In this work we intend to investigate this connection through the use of an …

Overcoming T cell dysfunction in acidic pH to enhance adoptive T cell transfer immunotherapy

F Navarro, N Casares, C Martín-Otal… - …, 2022 - Taylor & Francis
The high metabolic activity and insufficient perfusion of tumors leads to the acidification of
the tumor microenvironment (TME) that may inhibit the antitumor T cell activity. We found that …

[HTML][HTML] Blockage of FOXP3 transcription factor dimerization and FOXP3/AML1 interaction inhibits T regulatory cell activity: sequence optimization of a peptide inhibitor

T Lozano, M Gorraiz, A Lasarte-Cía, M Ruiz, O Rabal… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Although T regulatory cells (Treg) are essential for the prevention of autoimmune diseases,
their immunoregulatory function restrains the induction of immune responses against …

[HTML][HTML] Cold-inducible RNA binding protein as a vaccination platform to enhance immunotherapeutic responses against hepatocellular carcinoma

L Silva, J Egea, L Villanueva, M Ruiz, D Llopiz… - Cancers, 2020 - mdpi.com
Simple Summary Current immunotherapies based on blockade of immunosuppressive
elements provide limited results in liver cancer patients. Here we tested whether …

[HTML][HTML] Targeting the extra domain A of fibronectin for cancer therapy with CAR-T cells

C Martín-Otal, A Lasarte-Cia, D Serrano… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background One of the main difficulties of adoptive cell therapies with chimeric antigen
receptor (CAR)-T cells in solid tumors is the identification of specific target antigens. The …

Therapeutic effect of irreversible electroporation in combination with poly-ICLC adjuvant in preclinical models of hepatocellular carcinoma

I Vivas, K Iribarren, T Lozano, D Cano… - Journal of Vascular and …, 2019 - Elsevier
Purpose To evaluate the therapeutic efficacy of irreversible electroporation (IRE) combined
with the intratumoral injection of the immunogenic adjuvant poly-ICLC (polyinosinic …

[HTML][HTML] Intratumoral STING agonist injection combined with irreversible electroporation delays tumor growth in a model of hepatocarcinoma

A Lasarte-Cia, T Lozano, D Cano… - BioMed Research …, 2021 - hindawi.com
Background/Aim. Irreversible electroporation (IRE) showed promising results for small-size
tumors and very early cancers. However, further development is needed to evolve this …

[HTML][HTML] Immunomodulatory properties of carvone inhalation and its effects on contextual fear memory in mice

A Lasarte-Cia, T Lozano, M Pérez-González… - Frontiers in …, 2018 - frontiersin.org
A complex network of interactions exists between the immune, the olfactory, and the central
nervous system (CNS). Inhalation of different fragrances can affect immunological reactions …