[HTML][HTML] Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy

A Hanoteau, JM Newton, R Krupar, C Huang… - … for immunotherapy of …, 2019 - Springer
Background Chemoradiotherapy (CRT) remains one of the most common cancer treatment
modalities, and recent data suggest that CRT is maximally effective when there is generation …

[HTML][HTML] Immune microenvironment modulation unmasks therapeutic benefit of radiotherapy and checkpoint inhibition

JM Newton, A Hanoteau, HC Liu, A Gaspero… - … for immunotherapy of …, 2019 - Springer
Abstract Background Immune checkpoint inhibitors (ICIs) for solid tumors, including those
targeting programmed cell death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 …

TGF-β1 programmed myeloid-derived suppressor cells (MDSC) acquire immune-stimulating and tumor killing activity capable of rejecting established tumors in …

P Jayaraman, F Parikh, JM Newton, A Hanoteau… - …, 2018 - Taylor & Francis
Cancer-induced myeloid-derived suppressor cells (MDSC) play an important role in tumor
immune evasion. MDSC programming or polarization has been proposed as a strategy for …

Chemotherapy and immunotherapy: A close interplay to fight cancer?

A Hanoteau, M Moser - Oncoimmunology, 2016 - Taylor & Francis
In theory, the immunotherapy of cancer should induce the selective destruction of cancer
cells and a long-term specific protection, based on the specificity and memory of immunity …

Anti-tumor immunity induced by ectopic expression of viral antigens is transient and limited by immune escape

N Dharmaraj, SL Piotrowski, C Huang… - …, 2019 - Taylor & Francis
Immunotherapeutic treatments in head and neck cancer clinical trials include cancer
vaccines targeting foreign viral antigens or mutational neoantigens derived from cancer …

Cyclophosphamide treatment regulates the balance of functional/exhausted tumor-specific CD8+ T cells

A Hanoteau, C Henin, D Svec, C Bisilliat Donnet… - …, 2017 - Taylor & Francis
An important question is how chemotherapy may (re-) activate tumor-specific immunity. In
this study, we provide a phenotypic, functional and genomic analysis of tumor-specific CD8+ …

Cyclophosphamide treatment induces rejection of established P815 mastocytoma by enhancing CD4 priming and intratumoral infiltration of P1E/H‐2Kd‐specific CD8+ …

G Rahir, N Wathelet, A Hanoteau… - … journal of cancer, 2014 - Wiley Online Library
There is increasing evidence that the effect of chemotherapy on tumor growth is not cell
autonomous but relies on the immune system. The objective of this study was therefore to …

Enrichment and characterization of the tumor immune and non-immune microenvironments in established subcutaneous murine tumors

JM Newton, A Hanoteau, AG Sikora - JoVE (Journal of Visualized …, 2018 - jove.com
The tumor immune microenvironment (TIME) has recently been recognized as a critical
mediator of treatment response in solid tumors, especially for immunotherapies. Recent …

The interplay of immunotherapy and chemotherapy, a novel approach

A Hanoteau, C Henin, M Moser - Medecine Sciences: M/S, 2016 - europepmc.org
In the last decade, a growing body of evidence has highlighted the major role of cancer
immunosurveillance. The immune system can recognize tumor cells and keep them under …

[HTML][HTML] L'immunothérapie au service de la chimiothérapie, de nouvelles avancées

A Hanoteau, C Henin, M Moser - médecine/sciences, 2016 - medecinesciences.org
De nombreuses évidences expérimentales obtenues ces dernières années mettent en
évidence le rôle majeur de l'immunosurveillance des tumeurs. Le système immunitaire …