Cancer treatment has rapidly entered the age of immunotherapy, and it is becoming clear
that the effective therapy of established tumors necessitates rational multi-combination …

Cellular therapy has emerged as an attractive option for the treatment of cancer, and
adoptive transfer of chimeric antigen receptor (CAR) expressing T cells has gained FDA …

Endothelial lipase (LIPG) plays a critical role in lipoprotein metabolism, cytokine expression,
and the lipid composition of cells. Thus far, the extensive investigations of LIPG have …

Abstract Triple-negative (ER−, HER2−, PR−) breast cancer (TNBC) is an aggressive disease
with a poor prognosis with no available molecularly targeted therapy. Silencing of microRNA …

More than 40% of the US population are clinically obese and suffer from metabolic
syndrome with an increased risk of postmenopausal estrogen receptor-positive breast …

The tumor microenvironment plays a critical role in regulating breast tumor progression.
Signaling between preadipocytes and breast cancer cells has been found to promote breast …

Dysregulation of long non-codng RNA (lncRNA) expression has been found to contribute to
tumorigenesis. However, the roles of lncRNAs in BRCA1-related breast cancer remain …

An increasing body of evidence supports a stepwise model for progression of breast cancer
from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC). Due to the high …

Background Poly (ADP-ribose) polymerase inhibitors (PARPi) prevent single-stranded DNA
repair. Olaparib is a PARPi approved for the treatment of BRCA mutant ovarian and breast …

Background Natural killer (NK) cells are immune cells capable of killing virally infected cells
and tumor cells without the need for antigen stimulation. Tumors, however, can create a …