Background Interleukin-15 (IL-15) promotes growth and activation of cytotoxic CD8+ T and
natural killer (NK) cells. Bioactive IL-15 is produced in the body as a heterodimeric cytokine …

Immunotherapy has emerged as a viable approach in cancer therapy, with cytokines being
of great interest. Interleukin IL-15 (IL-15), a cytokine that supports cytotoxic immune cells …

Purpose: Adoptive cell transfer (ACT) is a promising immunotherapeutic approach for
cancer. Host lymphodepletion is associated with favorable ACT therapy outcomes, but it may …

Locoregional monotherapy with heterodimeric interleukin (IL)-15 (hetIL-15) in a triple-
negative breast cancer (TNBC) orthotopic mouse model resulted in tumor eradication in …

Simple Summary There is currently no effective therapy available for triple-negative breast
cancer. To look for potentially effective treatment, we used the 4T1 mouse model of triple …

Injectable scaffold delivery is a strategy to enhance the efficacy of cancer vaccine
immunotherapy. The choice of scaffold biomaterial is crucial, impacting both vaccine release …

Introduction: IL-15 is a cytokine important for the maintenance, proliferation and activation of
lymphocytes, including CD8+ T and natural killer (NK) cells. The native form of IL-15 is a …

Introduction: In this preclinical study, we tried to model the therapeutic strategies often used
in the clinic to treat breast cancer patients. We analyzed the role of hetIL 15 immunotherapy …