Cancer cells deviate from normal body cells in two immunologically important ways. First,
tumour cells carry tens to hundreds of protein‐changing mutations that are either …

Tumor antigen–specific T cells are found within melanomas, yet tumors continue to grow.
Although the tumor microenvironment is thought to influence the suppression of tumor …

Tumor Exome Analysis Reveals Neoantigen-Specific T-Cell Reactivity in an Ipilimumab-Responsive
Melanoma | Journal of Clinical Oncology Skip to main content ASCO Publications Publications …

Expression of the transcription factor Foxp3 (forkhead box P3) has been implicated as a key
element for CD25+ T regulatory cell function in mice. However, literature over similar …

Cell-based antitumor immunity is driven by CD8+ cytotoxic T cells bearing TCR that
recognize specific tumor-associated peptides bound to class I MHC molecules. Of several …

Introduction Ipilimumab, a cytotoxic T lymphocyte-associated antigen-4 blocking antibody,
has improved overall survival (OS) in metastatic melanoma in phase III trials. However …

Abstract Interleukin-17 (IL-17)–secreting CD8+ T cells have been described, but they have
not been thoroughly studied and they do not have a known role in cancer immunotherapy …

The transfer of T cell receptor (TCR) genes into patient T cells is a promising approach for
the treatment of both viral infections and cancer. Although efficient methods exist to identify …

There is strong evidence that both adoptive T cell transfer and T cell checkpoint blockade
can lead to regression of human melanoma. However, little data are available on the effect …

Adoptive cell transfer of tumor-infiltrating lymphocytes (TILs) after lymphodepletion mediates
regression in 50% of patients with metastatic melanoma. In vivo persistence and telomere …