Whole metagenome profiling reveals skin microbiome-dependent susceptibility to atopic dermatitis flare

KR Chng, ASL Tay, C Li, AHQ Ng, J Wang, BK Suri… - Nature …, 2016 - nature.com
Whole metagenome analysis has the potential to reveal functional triggers of skin diseases,
but issues of cost, robustness and sampling efficacy have limited its application. Here, we …

Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia

KS Robinson, DET Teo, KS Tan, GA Toh, HH Ong… - Science, 2020 - science.org
INTRODUCTION The innate immune system uses a variety of sensor proteins to detect
infections and injuries. The nucleotide-binding oligomerization domain, leucine-rich repeat …

High mitochondrial respiration and glycolytic capacity represent a metabolic phenotype of human tolerogenic dendritic cells

F Malinarich, K Duan, RA Hamid, A Bijin… - The Journal of …, 2015 - journals.aai.org
Human dendritic cells (DCs) regulate the balance between immunity and tolerance through
selective activation by environmental and pathogen-derived triggers. To characterize the …

[HTML][HTML] Immunohistochemical scoring of CD38 in the tumor microenvironment predicts responsiveness to anti-PD-1/PD-L1 immunotherapy in hepatocellular …

HHM Ng, RY Lee, S Goh, ISY Tay, X Lim… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Methods Clinically annotated samples from 49 patients with advanced HCC treated with ICB
were analyzed for CD38 expression using immunohistochemistry (IHC), multiplex …

[HTML][HTML] Met-Flow, a strategy for single-cell metabolic analysis highlights dynamic changes in immune subpopulations

PJ Ahl, RA Hopkins, WW Xiang, B Au… - Communications …, 2020 - nature.com
A complex interaction of anabolic and catabolic metabolism underpins the ability of
leukocytes to mount an immune response. Their capacity to respond to changing …

[HTML][HTML] Chromosomal instability-induced senescence potentiates cell non-autonomous tumourigenic effects

Q He, B Au, M Kulkarni, Y Shen, KJ Lim, J Maimaiti… - Oncogenesis, 2018 - nature.com
Chromosomal instability (CIN), a high rate of chromosome loss or gain, is often associated
with poor prognosis and drug resistance in cancers. Aneuploid, including near-polyploid …

[HTML][HTML] A phase I study of an adenoviral vector delivering a MUC1/CD40-ligand fusion protein in patients with advanced adenocarcinoma

TJ Tan, WXG Ang, WW Wang, HS Chong… - Nature …, 2022 - nature.com
Cancer vaccines as immunotherapy for solid tumours are currently in development with
promising results. We report a phase 1 study of Ad-sig-hMUC1/ecdCD40L (NCT02140996) …

[HTML][HTML] Induction of human T-cell and cytokine responses following vaccination with a novel influenza vaccine

DAG Skibinski, LA Jones, YO Zhu, LW Xue, B Au… - Scientific reports, 2018 - nature.com
Cell mediated immunity plays a vital role in defense against influenza infection in humans.
Less is known about the role of vaccine-induced cell mediated immunity and the cytokine …

[HTML][HTML] TLR7 protein expression in mild and severe lupus-prone models is regulated in a leukocyte, genetic, and IRAK4 dependent manner

T Celhar, HK Lu, L Benso, L Rakhilina, HY Lee… - Frontiers in …, 2019 - frontiersin.org
The global increase in autoimmunity, together with the emerging autoimmune-related side
effects of cancer immunotherapy, have furthered a need for understanding of immune …

A functional brain-derived neurotrophic factor (BDNF) gene variant increases the risk of moderate-to-severe allergic rhinitis

P Jin, AK Andiappan, JM Quek, B Lee, B Au… - Journal of Allergy and …, 2015 - Elsevier
Background Brain-derived neurotrophic factor (BDNF) is a secretory protein that has been
implicated in the pathogenesis of allergic rhinitis (AR), atopic asthma, and eczema, but it is …