Whole metagenome profiling reveals skin microbiome-dependent susceptibility to atopic dermatitis flare
Whole metagenome analysis has the potential to reveal functional triggers of skin diseases,
but issues of cost, robustness and sampling efficacy have limited its application. Here, we …
but issues of cost, robustness and sampling efficacy have limited its application. Here, we …
Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia
KS Robinson, DET Teo, KS Tan, GA Toh, HH Ong… - Science, 2020 - science.org
INTRODUCTION The innate immune system uses a variety of sensor proteins to detect
infections and injuries. The nucleotide-binding oligomerization domain, leucine-rich repeat …
infections and injuries. The nucleotide-binding oligomerization domain, leucine-rich repeat …
High mitochondrial respiration and glycolytic capacity represent a metabolic phenotype of human tolerogenic dendritic cells
F Malinarich, K Duan, RA Hamid, A Bijin… - The Journal of …, 2015 - journals.aai.org
Human dendritic cells (DCs) regulate the balance between immunity and tolerance through
selective activation by environmental and pathogen-derived triggers. To characterize the …
selective activation by environmental and pathogen-derived triggers. To characterize the …
[HTML][HTML] Immunohistochemical scoring of CD38 in the tumor microenvironment predicts responsiveness to anti-PD-1/PD-L1 immunotherapy in hepatocellular …
Methods Clinically annotated samples from 49 patients with advanced HCC treated with ICB
were analyzed for CD38 expression using immunohistochemistry (IHC), multiplex …
were analyzed for CD38 expression using immunohistochemistry (IHC), multiplex …
[HTML][HTML] Met-Flow, a strategy for single-cell metabolic analysis highlights dynamic changes in immune subpopulations
PJ Ahl, RA Hopkins, WW Xiang, B Au… - Communications …, 2020 - nature.com
A complex interaction of anabolic and catabolic metabolism underpins the ability of
leukocytes to mount an immune response. Their capacity to respond to changing …
leukocytes to mount an immune response. Their capacity to respond to changing …
[HTML][HTML] Chromosomal instability-induced senescence potentiates cell non-autonomous tumourigenic effects
Q He, B Au, M Kulkarni, Y Shen, KJ Lim, J Maimaiti… - Oncogenesis, 2018 - nature.com
Chromosomal instability (CIN), a high rate of chromosome loss or gain, is often associated
with poor prognosis and drug resistance in cancers. Aneuploid, including near-polyploid …
with poor prognosis and drug resistance in cancers. Aneuploid, including near-polyploid …
[HTML][HTML] A phase I study of an adenoviral vector delivering a MUC1/CD40-ligand fusion protein in patients with advanced adenocarcinoma
Cancer vaccines as immunotherapy for solid tumours are currently in development with
promising results. We report a phase 1 study of Ad-sig-hMUC1/ecdCD40L (NCT02140996) …
promising results. We report a phase 1 study of Ad-sig-hMUC1/ecdCD40L (NCT02140996) …
[HTML][HTML] Induction of human T-cell and cytokine responses following vaccination with a novel influenza vaccine
DAG Skibinski, LA Jones, YO Zhu, LW Xue, B Au… - Scientific reports, 2018 - nature.com
Cell mediated immunity plays a vital role in defense against influenza infection in humans.
Less is known about the role of vaccine-induced cell mediated immunity and the cytokine …
Less is known about the role of vaccine-induced cell mediated immunity and the cytokine …
[HTML][HTML] TLR7 protein expression in mild and severe lupus-prone models is regulated in a leukocyte, genetic, and IRAK4 dependent manner
T Celhar, HK Lu, L Benso, L Rakhilina, HY Lee… - Frontiers in …, 2019 - frontiersin.org
The global increase in autoimmunity, together with the emerging autoimmune-related side
effects of cancer immunotherapy, have furthered a need for understanding of immune …
effects of cancer immunotherapy, have furthered a need for understanding of immune …
A functional brain-derived neurotrophic factor (BDNF) gene variant increases the risk of moderate-to-severe allergic rhinitis
P Jin, AK Andiappan, JM Quek, B Lee, B Au… - Journal of Allergy and …, 2015 - Elsevier
Background Brain-derived neurotrophic factor (BDNF) is a secretory protein that has been
implicated in the pathogenesis of allergic rhinitis (AR), atopic asthma, and eczema, but it is …
implicated in the pathogenesis of allergic rhinitis (AR), atopic asthma, and eczema, but it is …