User profiles for "author:Brian Gastman"

Brian Gastman

Professor Surgery, Cleveland Clinic Lerner College of Medicine
Verified email at ccf.org
Cited by 7902

What is the best surgical margin for a Basal cell carcinoma: a meta-analysis of the literature

Y Gulleth, N Goldberg, RP Silverman… - Plastic and …, 2010 - journals.lww.com
Background: Current management of basal cell carcinoma is surgical excision. Most
resections use predetermined surgical margins. The basis of ideal resection margins is …

Inferior outcomes in immunosuppressed patients with high-risk cutaneous squamous cell carcinoma of the head and neck treated with surgery and radiation therapy

BV Manyam, B Gastman, AY Zhang, CA Reddy… - Journal of the American …, 2015 - Elsevier
Background Immunosuppressed patients have higher rates of cutaneous squamous cell
carcinoma of the head and neck. Objective This study reviews the effect of immune status on …

NCCN Guidelines® insights: melanoma: cutaneous, version 2.2021: featured updates to the NCCN guidelines

SM Swetter, JA Thompson, MR Albertini… - Journal of the National …, 2021 - jnccn.org
Over the past few years, the NCCN Guidelines for Melanoma: Cutaneous have been
expanded to include pathways for treatment of microscopic satellitosis (added in v2. 2020) …

Malignant melanoma: diagnostic and management update

T Knackstedt, RW Knackstedt, R Couto… - Plastic and …, 2018 - journals.lww.com
Strides in melanoma surveillance, detection, and treatment continue to be made. The
American Joint Committee on Cancer Eighth Edition Cancer Staging System has improved …

Cutaneous melanoma, version 2.2019, NCCN clinical practice guidelines in oncology

DG Coit, JA Thompson, MR Albertini, C Barker… - Journal of the National …, 2019 - jnccn.org
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Cutaneous
melanoma have been significantly revised over the past few years in response to emerging …

Human γδ T lymphocytes induce robust NK cell–mediated antitumor cytotoxicity through CD137 engagement

A Maniar, X Zhang, W Lin, BR Gastman… - Blood, The Journal …, 2010 - ashpublications.org
Natural killer (NK) cells are innate effector lymphocytes that control the growth of major
histocompatibility complex class I negative tumors. We show here that γδ T lymphocytes …

Merkel cell carcinoma, version 1.2018, NCCN clinical practice guidelines in oncology

CK Bichakjian, T Olencki, SZ Aasi, M Alam… - Journal of the National …, 2018 - jnccn.org
This selection from the NCCN Guidelines for Merkel Cell Carcinoma (MCC) focuses on
areas impacted by recently emerging data, including sections describing MCC risk factors …

Fas ligand is expressed on human squamous cell carcinomas of the head and neck, and it promotes apoptosis of T lymphocytes

BR Gastman, Y Atarashi, TE Reichert, T Saito, L Balkir… - Cancer research, 1999 - AACR
Recent reports have variously described expression of Fas ligand (FasL) or its absence in
human tumors. The importance of the Fas-FasL mechanism for the immune evasion by …

A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4–ERK5 axis

L Wu, X Chen, J Zhao, B Martin, JA Zepp… - Journal of Experimental …, 2015 - rupress.org
Although IL-17 is emerging as an important cytokine in cancer promotion and progression,
the underlining molecular mechanism remains unclear. Previous studies suggest that IL-17 …

[HTML][HTML] Adjuvant nivolumab in resected stage IIB/C melanoma: primary results from the randomized, phase 3 CheckMate 76K trial

JM Kirkwood, M Del Vecchio, J Weber, C Hoeller… - Nature Medicine, 2023 - nature.com
Patients with resected stage IIB/C melanoma have high recurrence risk, similar to those with
resected stage IIIA/B disease. The phase 3, double-blind CheckMate 76K trial assessed 790 …