Use of historical control data for assessing treatment effects in clinical trials
K Viele, S Berry, B Neuenschwander… - Pharmaceutical …, 2014 - Wiley Online Library
Clinical trials rarely, if ever, occur in a vacuum. Generally, large amounts of clinical data are
available prior to the start of a study, particularly on the current study's control arm. There is …
available prior to the start of a study, particularly on the current study's control arm. There is …
Genetics of chronic obstructive pulmonary disease: understanding the pathobiology and heterogeneity of a complex disorder
MH Cho, BD Hobbs, EK Silverman - The Lancet Respiratory …, 2022 - thelancet.com
Chronic obstructive pulmonary disease (COPD) is a deadly and highly morbid disease.
Susceptibility to and heterogeneity of COPD are incompletely explained by environmental …
Susceptibility to and heterogeneity of COPD are incompletely explained by environmental …
Randomized controlled trials
Randomized controlled trials (RCTs) are considered the highest level of evidence to
establish causal associations in clinical research. There are many RCT designs and …
establish causal associations in clinical research. There are many RCT designs and …
[HTML][HTML] Improved axillary evaluation following neoadjuvant therapy for patients with node-positive breast cancer using selective evaluation of clipped nodes …
AS Caudle, WT Yang, S Krishnamurthy… - Journal of Clinical …, 2016 - ncbi.nlm.nih.gov
Purpose Placing clips in nodes with biopsy-confirmed metastasis before initiating
neoadjuvant therapy allows for evaluation of response in breast cancer. Our goal was to …
neoadjuvant therapy allows for evaluation of response in breast cancer. Our goal was to …
Pembrolizumab with or without radiotherapy for metastatic non-small-cell lung cancer: a pooled analysis of two randomised trials
WSME Theelen, D Chen, V Verma… - The Lancet …, 2021 - thelancet.com
Background Radiotherapy might augment systemic antitumoral responses to
immunotherapy. In the PEMBRO-RT (phase 2) and MDACC (phase 1/2) trials, patients with …
immunotherapy. In the PEMBRO-RT (phase 2) and MDACC (phase 1/2) trials, patients with …
A new framework for understanding organisational project management through the PMO
This paper presents a theoretical contribution to the study of organisational project
management and of the project management office (PMO). The PMO should no longer be …
management and of the project management office (PMO). The PMO should no longer be …
Inelastic design of infilled frames
A Saneinejad, B Hobbs - Journal of structural engineering, 1995 - ascelibrary.org
This paper describes a new method of analysis and design for steel frames with concrete or
masonry infilling walls subjected to in-plane forces. The method is based on data generated …
masonry infilling walls subjected to in-plane forces. The method is based on data generated …
The perceived value and potential contribution of project management practices to project success
C Besner, B Hobbs - Project management journal, 2006 - journals.sagepub.com
This paper contributes to the ongoing work and debate on the value of project management,
accomplishing this through an empirical investigation of practitioner perceptions on the …
accomplishing this through an empirical investigation of practitioner perceptions on the …
A multi-phase research program investigating project management offices (PMOs): the results of phase 1
Over the last decade, the project management office (PMO) has become a prominent feature
in many organizations. Despite the proliferation of PMOs in practice, our understanding of …
in many organizations. Despite the proliferation of PMOs in practice, our understanding of …
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide.
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
We performed a genetic association study in 15,256 cases and 47,936 controls, with …