User profiles for "author:Bruce Walcheck"
Bruce WalcheckVerified email at umn.edu Cited by 6949 |
Role of ADAM17 as a regulatory checkpoint of CD16A in NK cells and as a potential target for cancer immunotherapy
J Wu, HK Mishra, B Walcheck - Journal of leukocyte biology, 2019 - academic.oup.com
Human NK cell antitumor activities involve Ab-dependent cell-mediated cytotoxicity (ADCC),
which is a key mechanism of action for several clinically successful tumor-targeting …
which is a key mechanism of action for several clinically successful tumor-targeting …
NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)
The Fc receptor CD16 is present on essentially all CD56dim peripheral blood natural killer
(NK) cells. Upon recognition of antibody-coated cells it delivers a potent signal to NK cells …
(NK) cells. Upon recognition of antibody-coated cells it delivers a potent signal to NK cells …
[HTML][HTML] Engineering anti-tumor monoclonal antibodies and Fc receptors to enhance ADCC by human NK cells
Simple Summary Human natural killer (NK) cells can be targeted to tumor antigens by their
IgG Fc receptors that interact with the Fc regions of antibodies that recognize surface …
IgG Fc receptors that interact with the Fc regions of antibodies that recognize surface …
Neutrophil-neutrophil interactions under hydrodynamic shear stress involve L-selectin and PSGL-1. A mechanism that amplifies initial leukocyte accumulation of P …
B Walcheck, KL Moore, RP McEver… - The Journal of …, 1996 - Am Soc Clin Investig
Leukocytes attach to and roll on inflamed endothelium and on leukocyte monolayers that
form on the endothelial cells. Leukocyte-leukocyte interactions occurring under …
form on the endothelial cells. Leukocyte-leukocyte interactions occurring under …
Neutrophil rolling altered by inhibition of L-selectin shedding in vitro
B Walcheck, J Kahn, JM Fisher, BB Wang, RS Fisk… - Nature, 1996 - nature.com
THE L-selectin adhesion molecule is involved in guiding leuko-cytes to sites of
inflammation1. L-selectin is cleaved by an unusual proteolytic activity at a membrane …
inflammation1. L-selectin is cleaved by an unusual proteolytic activity at a membrane …
[HTML][HTML] Ectodomain shedding by ADAM17: its role in neutrophil recruitment and the impairment of this process during sepsis
HK Mishra, J Ma, B Walcheck - Frontiers in Cellular and Infection …, 2017 - frontiersin.org
Neutrophils are specialized at killing bacteria and are recruited from the blood in a rapid and
robust manner during infection. A cascade of adhesion events direct their attachment to the …
robust manner during infection. A cascade of adhesion events direct their attachment to the …
Targeting Natural Killer Cells to Acute Myeloid Leukemia In Vitro with a CD16 × 33 Bispecific Killer Cell Engager and ADAM17 Inhibition
A Wiernik, B Foley, B Zhang, MR Verneris, E Warlick… - Clinical cancer …, 2013 - AACR
Purpose: The graft versus leukemia effect by natural killer (NK) cells prevents relapse
following hematopoietic stem cell transplantation. We determined whether a novel bispecific …
following hematopoietic stem cell transplantation. We determined whether a novel bispecific …
Functional interactions between tumor and peripheral nerve: morphology, algogen identification, and behavioral characterization of a new murine model of cancer …
PW Wacnik, LJ Eikmeier, TR Ruggles… - Journal of …, 2001 - Soc Neuroscience
This paper describes a model of tumor-induced bone destruction and hyperalgesia
produced by implantation of fibrosarcoma cells into the mouse calcaneus bone. Histological …
produced by implantation of fibrosarcoma cells into the mouse calcaneus bone. Histological …
Role of ADAM17 in the ectodomain shedding of TNF-α and its receptors by neutrophils and macrophages
JH Bell, AH Herrera, Y Li… - Journal of Leucocyte …, 2007 - academic.oup.com
TNF-α and its receptors TNFRI and TNFRII are cleaved from the surface of leukocytes by a
proteolytic process referred to as ectodomain shedding. The role of a disintegrin and …
proteolytic process referred to as ectodomain shedding. The role of a disintegrin and …
Pluripotent stem cell–derived NK cells with high-affinity noncleavable CD16a mediate improved antitumor activity
H Zhu, RH Blum, R Bjordahl… - Blood, The Journal …, 2020 - ashpublications.org
Antibody-dependent cellular cytotoxicity (ADCC) is a key effector mechanism of natural killer
(NK) cells that is mediated by therapeutic monoclonal antibodies (mAbs). This process is …
(NK) cells that is mediated by therapeutic monoclonal antibodies (mAbs). This process is …