User profiles for "author:Bruce Walcheck"

Bruce Walcheck

Verified email at umn.edu
Cited by 6949

Role of ADAM17 as a regulatory checkpoint of CD16A in NK cells and as a potential target for cancer immunotherapy

J Wu, HK Mishra, B Walcheck - Journal of leukocyte biology, 2019 - academic.oup.com
Human NK cell antitumor activities involve Ab-dependent cell-mediated cytotoxicity (ADCC),
which is a key mechanism of action for several clinically successful tumor-targeting …

NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)

R Romee, B Foley, T Lenvik, Y Wang… - Blood, The Journal …, 2013 - ashpublications.org
The Fc receptor CD16 is present on essentially all CD56dim peripheral blood natural killer
(NK) cells. Upon recognition of antibody-coated cells it delivers a potent signal to NK cells …

[HTML][HTML] Engineering anti-tumor monoclonal antibodies and Fc receptors to enhance ADCC by human NK cells

KJ Dixon, J Wu, B Walcheck - Cancers, 2021 - mdpi.com
Simple Summary Human natural killer (NK) cells can be targeted to tumor antigens by their
IgG Fc receptors that interact with the Fc regions of antibodies that recognize surface …

Neutrophil-neutrophil interactions under hydrodynamic shear stress involve L-selectin and PSGL-1. A mechanism that amplifies initial leukocyte accumulation of P …

B Walcheck, KL Moore, RP McEver… - The Journal of …, 1996 - Am Soc Clin Investig
Leukocytes attach to and roll on inflamed endothelium and on leukocyte monolayers that
form on the endothelial cells. Leukocyte-leukocyte interactions occurring under …

Neutrophil rolling altered by inhibition of L-selectin shedding in vitro

B Walcheck, J Kahn, JM Fisher, BB Wang, RS Fisk… - Nature, 1996 - nature.com
THE L-selectin adhesion molecule is involved in guiding leuko-cytes to sites of
inflammation1. L-selectin is cleaved by an unusual proteolytic activity at a membrane …

[HTML][HTML] Ectodomain shedding by ADAM17: its role in neutrophil recruitment and the impairment of this process during sepsis

HK Mishra, J Ma, B Walcheck - Frontiers in Cellular and Infection …, 2017 - frontiersin.org
Neutrophils are specialized at killing bacteria and are recruited from the blood in a rapid and
robust manner during infection. A cascade of adhesion events direct their attachment to the …

Targeting Natural Killer Cells to Acute Myeloid Leukemia In Vitro with a CD16 × 33 Bispecific Killer Cell Engager and ADAM17 Inhibition

A Wiernik, B Foley, B Zhang, MR Verneris, E Warlick… - Clinical cancer …, 2013 - AACR
Purpose: The graft versus leukemia effect by natural killer (NK) cells prevents relapse
following hematopoietic stem cell transplantation. We determined whether a novel bispecific …

Functional interactions between tumor and peripheral nerve: morphology, algogen identification, and behavioral characterization of a new murine model of cancer …

PW Wacnik, LJ Eikmeier, TR Ruggles… - Journal of …, 2001 - Soc Neuroscience
This paper describes a model of tumor-induced bone destruction and hyperalgesia
produced by implantation of fibrosarcoma cells into the mouse calcaneus bone. Histological …

Role of ADAM17 in the ectodomain shedding of TNF-α and its receptors by neutrophils and macrophages

JH Bell, AH Herrera, Y Li… - Journal of Leucocyte …, 2007 - academic.oup.com
TNF-α and its receptors TNFRI and TNFRII are cleaved from the surface of leukocytes by a
proteolytic process referred to as ectodomain shedding. The role of a disintegrin and …

Pluripotent stem cell–derived NK cells with high-affinity noncleavable CD16a mediate improved antitumor activity

H Zhu, RH Blum, R Bjordahl… - Blood, The Journal …, 2020 - ashpublications.org
Antibody-dependent cellular cytotoxicity (ADCC) is a key effector mechanism of natural killer
(NK) cells that is mediated by therapeutic monoclonal antibodies (mAbs). This process is …