Molecular pathways: next-generation immunotherapy—inhibiting programmed death-ligand 1 and programmed death-1
The aim of T-cell–based immune therapy for cancer has been to generate durable clinical
benefit for patients. Following a generation of therapies that largely showed minimal activity …
benefit for patients. Following a generation of therapies that largely showed minimal activity …
The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways
The function of the T cell antigen receptor (TM) invariant chains, CD3 y, S, E, and<, is poorly
understood. Evidence suggests that CD3 couples receptor ligand binding to intracellular …
understood. Evidence suggests that CD3 couples receptor ligand binding to intracellular …
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
The T cell antigen receptor (TCR) initiates signals by interacting with cytoplasmic protein
tyrosine kinases (PTKs) through a 17-residue sequence motif [called the antigen recognition …
tyrosine kinases (PTKs) through a 17-residue sequence motif [called the antigen recognition …
Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28
The mechanism by which cell surface molecules regulate T cell production of lymphokines is
poorly understood. Production of interleukin-2 (IL-2) can be regulated by signal transduction …
poorly understood. Production of interleukin-2 (IL-2) can be regulated by signal transduction …
Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs
JM Turner, MH Brodsky, BA Irving, SD Levin… - Cell, 1990 - cell.com
56”~, a lymphocyte-specific member of the SIC family of cytoplasmic protein-tyrosine
kinases, is associated noncovalently with the cell surface glycoproteins CD4 and CD8 …
kinases, is associated noncovalently with the cell surface glycoproteins CD4 and CD8 …
The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein.
Stimulation of the T-cell antigen receptor (TCR) leads to tyrosine phosphorylation of a
number of cellular proteins, including phospholipase C (PLC) gamma 1 and the TCR zeta …
number of cellular proteins, including phospholipase C (PLC) gamma 1 and the TCR zeta …
[PDF][PDF] MAP kinase inhibition promotes T cell and anti-tumor activity in combination with PD-L1 checkpoint blockade
PJR Ebert, J Cheung, Y Yang, E McNamara, R Hong… - Immunity, 2016 - cell.com
Targeted inhibition of mitogen-activated protein kinase (MAPK) kinase (MEK) can induce
regression of tumors bearing activating mutations in the Ras pathway but rarely leads to …
regression of tumors bearing activating mutations in the Ras pathway but rarely leads to …
Role of PD-1 during effector CD8 T cell differentiation
PD-1 (programmed cell death-1) is the central inhibitory receptor regulating CD8 T cell
exhaustion during chronic viral infection and cancer. Interestingly, PD-1 is also expressed …
exhaustion during chronic viral infection and cancer. Interestingly, PD-1 is also expressed …
Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain.
A conserved sequence motif has been identified in a number of signaling subunits
associated with hematopoietic cell antigen receptors. Here, we characterize signaling by a …
associated with hematopoietic cell antigen receptors. Here, we characterize signaling by a …
Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains
BA Irving, FW Alt, N Killeen - Science, 1998 - science.org
Immature thymocytes express a pre–T cell receptor (pre-TCR) composed of the TCRβ chain
paired with pre-Tα. Signals from this receptor are essential for passage of thymocytes …
paired with pre-Tα. Signals from this receptor are essential for passage of thymocytes …