Imaging and photodynamic therapy: mechanisms, monitoring, and optimization

JP Celli, BQ Spring, I Rizvi, CL Evans… - Chemical …, 2010 - ACS Publications
The purpose of this review is to present the current state of the role of imaging in
photodynamic therapy (PDT). For the reader to fully appreciate the context of the discussions …

The role of photodynamic therapy in overcoming cancer drug resistance

BQ Spring, I Rizvi, N Xu, T Hasan - Photochemical & photobiological …, 2015 - pubs.rsc.org
Many modalities of cancer therapy induce mechanisms of treatment resistance and escape
pathways during chronic treatments, including photodynamic therapy (PDT). It is …

A photoactivable multi-inhibitor nanoliposome for tumour control and simultaneous inhibition of treatment escape pathways

BQ Spring, R Bryan Sears, LZ Zheng, Z Mai… - Nature …, 2016 - nature.com
Nanoscale drug delivery vehicles can facilitate multimodal therapies of cancer by promoting
tumour-selective drug release. However, few are effective because cancer cells develop …

Optical imaging, photodynamic therapy and optically triggered combination treatments

S Mallidi, BQ Spring, S Chang, B Vakoc… - The Cancer …, 2015 - journals.lww.com
Optical imaging is becoming increasingly promising for real-time image-guided resections,
and combined with photodynamic therapy (PDT), a photochemistry-based treatment …

Dipole Strengths in the Chlorophylls¶

RS Knox, BQ Spring - Photochemistry and Photobiology, 2003 - Wiley Online Library
Measurements of dipole strengths of chlorophylls in solution are reviewed and correlated.
The refractive index dependence is found to be expressible in a simple empirical fashion …

Selective treatment and monitoring of disseminated cancer micrometastases in vivo using dual-function, activatable immunoconjugates

BQ Spring, AO Abu-Yousif… - Proceedings of the …, 2014 - National Acad Sciences
Drug-resistant micrometastases that escape standard therapies often go undetected until the
emergence of lethal recurrent disease. Here, we show that it is possible to treat microscopic …

Simultaneous delivery of cytotoxic and biologic therapeutics using nanophotoactivatable liposomes enhances treatment efficacy in a mouse model of pancreatic …

S Tangutoori, BQ Spring, Z Mai, A Palanisami… - … , Biology and Medicine, 2016 - Elsevier
A lack of intracellular delivery systems has limited the use of biologics such as monoclonal
antibodies (mAb) that abrogate molecular signaling pathways activated to promote escape …

Engineering redox-sensitive linkers for genetically encoded FRET-based biosensors

VL Kolossov, BQ Spring, A Sokolowski… - Experimental …, 2008 - journals.sagepub.com
The ability to sense intracellular or intraorganellar reduction/oxidation conditions would
provide a powerful tool for studying normal cell proliferation, differentiation, and apoptosis …

[HTML][HTML] High-power light-emitting diode array design and assembly for practical photodynamic therapy research

EM Kercher, K Zhang, M Waguespack… - … of biomedical optics, 2020 - spiedigitallibrary.org
Significance: Commercial lasers, lamps, and light-emitting diode (LED) light sources have
stimulated the clinical translation of photodynamic therapy (PDT). Yet, the continued …

[HTML][HTML] Custom fabrication and mode-locked operation of a femtosecond fiber laser for multiphoton microscopy

N Davoudzadeh, G Ducourthial, BQ Spring - Scientific reports, 2019 - nature.com
Solid-state femtosecond lasers have stimulated the broad adoption of multiphoton
microscopy in the modern laboratory. However, these devices remain costly. Fiber lasers …