User profiles for "author:Canping Chen"
Canping ChenOREGON HEALTH & SCIENCE UNIVERSITY Verified email at ohsu.edu Cited by 184 |
Identifying novel factors associated with COVID-19 transmission and fatality using the machine learning approach
The COVID-19 virus has infected more than 38 million people and resulted in more than one
million deaths worldwide as of October 14, 2020. By using the logistic regression model, we …
million deaths worldwide as of October 14, 2020. By using the logistic regression model, we …
Supervised learning of high-confidence phenotypic subpopulations from single-cell data
Accurately identifying phenotype-relevant cell subsets from heterogeneous cell populations
is crucial for delineating the underlying mechanisms driving biological or clinical …
is crucial for delineating the underlying mechanisms driving biological or clinical …
[HTML][HTML] Pharmacologic targeting of Nedd8-activating enzyme reinvigorates T-cell responses in lymphoid neoplasia
X Wang, C Chen, D Vuong, S Rodriguez-Rodriguez… - Leukemia, 2023 - nature.com
Neddylation is a sequential enzyme-based process which regulates the function of E3 Cullin-
RING ligase (CRL) and thus degradation of substrate proteins. Here we show that CD8+ T …
RING ligase (CRL) and thus degradation of substrate proteins. Here we show that CD8+ T …
DITHER: an algorithm for defining intratumor heterogeneity based on entropy
Intratumor heterogeneity (ITH) is associated with tumor development, prognosis, immune
evasion and therapeutic effects. We proposed the Defining ITH based on EntRopy (DITHER) …
evasion and therapeutic effects. We proposed the Defining ITH based on EntRopy (DITHER) …
Predicting the epidemic trend of COVID-19 in China and across the world using the machine learning approach
Background Although COVID-19 has been well controlled in China, it is rapidly spreading
outside the country and may have catastrophic results globally without implementation of …
outside the country and may have catastrophic results globally without implementation of …
[HTML][HTML] Pan-Cancer Analysis Reveals That E1A Binding Protein p300 Mutations Increase Genome Instability and Antitumor Immunity
Z Chen, C Chen, L Li, T Zhang, X Wang - Frontiers in Cell and …, 2021 - frontiersin.org
E1A binding protein p300 (EP300) is mutated in diverse cancers. Nevertheless, a systematic
investigation into the associations of EP300 mutations with genome instability and antitumor …
investigation into the associations of EP300 mutations with genome instability and antitumor …
[HTML][HTML] KALRN mutations promote antitumor immunity and immunotherapy response in cancer
Background kalirin RhoGEF kinase (KALRN) is mutated in a wide range of cancers.
Nevertheless, the association between KALRN mutations and the pathogenesis of cancer …
Nevertheless, the association between KALRN mutations and the pathogenesis of cancer …
[HTML][HTML] The spliceosome pathway activity correlates with reduced anti-tumor immunity and immunotherapy response, and unfavorable clinical outcomes in pan …
Z Chen, C Chen, L Li, T Zhang, X Wang - Computational and structural …, 2021 - Elsevier
Alterations in the spliceosome pathway (SP) have been associated with diverse human
cancers. In this study, we explored associations of the SP activity with various clinical …
cancers. In this study, we explored associations of the SP activity with various clinical …
Identification of prostate cancer subtypes based on immune signature scores in bulk and single-cell transcriptomes
C Chen, J Luo, X Wang - Medical Oncology, 2022 - Springer
Prostate cancer (PC) is heterogeneous in the tumor immune microenvironment (TIME).
Subtyping of PC based on the TIME could provide new insights into intratumor heterogeneity …
Subtyping of PC based on the TIME could provide new insights into intratumor heterogeneity …
[HTML][HTML] Pevonedistat, a Nedd8-activating enzyme inhibitor, in combination with ibrutinib in patients with relapsed/refractory B-cell non-Hodgkin lymphoma
P Torka, S Kambhampati, L Chen, X Wang… - Blood cancer …, 2023 - nature.com
Pevonedistat (TAK924) is a Nedd8-activating enzyme inhibitor with preclinical activity in non-
Hodgkin lymphoma (NHL). This open-label, Phase I, multicenter, investigator-sponsored …
Hodgkin lymphoma (NHL). This open-label, Phase I, multicenter, investigator-sponsored …