User profiles for "author:Canping Chen"

Canping Chen

OREGON HEALTH & SCIENCE UNIVERSITY
Verified email at ohsu.edu
Cited by 184

Identifying novel factors associated with COVID-19 transmission and fatality using the machine learning approach

M Li, Z Zhang, W Cao, Y Liu, B Du, C Chen… - Science of the Total …, 2021 - Elsevier
The COVID-19 virus has infected more than 38 million people and resulted in more than one
million deaths worldwide as of October 14, 2020. By using the logistic regression model, we …

Supervised learning of high-confidence phenotypic subpopulations from single-cell data

T Ren, C Chen, AV Danilov, S Liu, X Guan… - Nature Machine …, 2023 - nature.com
Accurately identifying phenotype-relevant cell subsets from heterogeneous cell populations
is crucial for delineating the underlying mechanisms driving biological or clinical …

[HTML][HTML] Pharmacologic targeting of Nedd8-activating enzyme reinvigorates T-cell responses in lymphoid neoplasia

X Wang, C Chen, D Vuong, S Rodriguez-Rodriguez… - Leukemia, 2023 - nature.com
Neddylation is a sequential enzyme-based process which regulates the function of E3 Cullin-
RING ligase (CRL) and thus degradation of substrate proteins. Here we show that CD8+ T …

DITHER: an algorithm for defining intratumor heterogeneity based on entropy

L Li, C Chen, X Wang - Briefings in Bioinformatics, 2021 - academic.oup.com
Intratumor heterogeneity (ITH) is associated with tumor development, prognosis, immune
evasion and therapeutic effects. We proposed the Defining ITH based on EntRopy (DITHER) …

Predicting the epidemic trend of COVID-19 in China and across the world using the machine learning approach

M Li, Z Zhang, S Jiang, Q Liu, C Chen, Y Zhang… - medRxiv, 2020 - medrxiv.org
Background Although COVID-19 has been well controlled in China, it is rapidly spreading
outside the country and may have catastrophic results globally without implementation of …

[HTML][HTML] Pan-Cancer Analysis Reveals That E1A Binding Protein p300 Mutations Increase Genome Instability and Antitumor Immunity

Z Chen, C Chen, L Li, T Zhang, X Wang - Frontiers in Cell and …, 2021 - frontiersin.org
E1A binding protein p300 (EP300) is mutated in diverse cancers. Nevertheless, a systematic
investigation into the associations of EP300 mutations with genome instability and antitumor …

[HTML][HTML] KALRN mutations promote antitumor immunity and immunotherapy response in cancer

M Li, Y Ma, Y Zhong, Q Liu, C Chen… - … for Immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background kalirin RhoGEF kinase (KALRN) is mutated in a wide range of cancers.
Nevertheless, the association between KALRN mutations and the pathogenesis of cancer …

[HTML][HTML] The spliceosome pathway activity correlates with reduced anti-tumor immunity and immunotherapy response, and unfavorable clinical outcomes in pan …

Z Chen, C Chen, L Li, T Zhang, X Wang - Computational and structural …, 2021 - Elsevier
Alterations in the spliceosome pathway (SP) have been associated with diverse human
cancers. In this study, we explored associations of the SP activity with various clinical …

Identification of prostate cancer subtypes based on immune signature scores in bulk and single-cell transcriptomes

C Chen, J Luo, X Wang - Medical Oncology, 2022 - Springer
Prostate cancer (PC) is heterogeneous in the tumor immune microenvironment (TIME).
Subtyping of PC based on the TIME could provide new insights into intratumor heterogeneity …

[HTML][HTML] Pevonedistat, a Nedd8-activating enzyme inhibitor, in combination with ibrutinib in patients with relapsed/refractory B-cell non-Hodgkin lymphoma

P Torka, S Kambhampati, L Chen, X Wang… - Blood cancer …, 2023 - nature.com
Pevonedistat (TAK924) is a Nedd8-activating enzyme inhibitor with preclinical activity in non-
Hodgkin lymphoma (NHL). This open-label, Phase I, multicenter, investigator-sponsored …