Abstract Combined PD-1 and CTLA-4-targeted immunotherapy with nivolumab and
ipilimumab is effective against melanoma, renal cell carcinoma and non-small-cell lung …

Neurophysiological and behavioral development is particularly complex in adolescence.
Youngsters experience strong emotions and impulsivity, reduced self-control, and …

Mycoplasma bovis and Mycoplasma agalactiae are two very closely related species which
cause mastitis in cows and goats, respectively. M. bovis can also cause arthritis and …

Poly I: C is a powerful immune adjuvant as a result of its agonist activities on TLR-3, MDA5
and RIG-I. BO-112 is a nanoplexed formulation of Poly I: C complexed with polyethylenimine …

Background BO-112 is a nanoplexed form of polyinosinic: polycytidylic acid that acting on
toll-like receptor 3 (TLR3), melanoma differentiation-associated protein 5 (MDA5) and …

N-Acetylcystelne (NAC) is highly nontoxic for peripheral blood T cells and
immunostimulatory enhancing T cell functions such as mitogenesis, interleukin-2 (IL-2) …

Abstract Fe 2 O 3-TiO 2-clay heterostructures have been prepared using an organo-
bentonite as support, which organophilic character favored the fixation of TiO 2 …

MCM-41 based catalysts (molar ratio Si/Al= 40) were prepared by a hydrothermal route,
modified by ionic exchange with different metals (Cu, Cr, Fe and Zn) and finally calcined at …

Activation-induced cell death (AICD) is a complex immunoregulatory mechanism that
causes the demise of a fraction of T-lymphocytes upon antigen-driven activation. In the …

The ability of conventional type-1 dendritic cells (cDC1) to cross-present tumor antigens to
CD8+ T cells is critical for the induction of antitumor CTLs. Mice that are constitutively …